Others

(rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus.

Glucocorticoid receptor agonist-3 (Preparation 6) is a glucocorticoid receptor agonist.

JA397, a chemical probe, is a potent and selective inhibitor for the TAIRE family with cellular activity ranging from IC₅₀ values of 21 nM to 307 nM.

DSPE-PEG5000-Fluor 647 is a fluorescent lipid (Ex/Em=648/671 nm) composed of PEG-lipid-dye conjugation. DSPE is a phospholipid. Fluor 647 is a fluorescent dye. DSPE-PEG5000-Fluor 647 can be used to prepare nanoparticles or liposomes with fluorescent signals.

G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs).

Biotin-16-dCTP is a biotinylated deoxycytidine triphosphate that serves as an important DNA labeling substrate. Biotin-16-dCTP can be enzymatically incorporated into the 3' end of DNA probes via terminal deoxynucleotidyl transferase, forming a 1-3 nucleotide-long tail to achieve biotinylation of the probes. Biotin-16-dCTP enhances chemiluminescent detection of low-abundance targets such as specific tRNA isoacceptors through Northern blotting. Biotin-16-dCTP can also replace conventional dCTP to be integrated into single-stranded DNA generated by asymmetric polymerase chain reaction, which is applicable for bioconjugation or pull-down assays. Repeated freeze-thaw cycles of Biotin-16-dCTP should be avoided to prevent degradation of its function for probe biotinylation.

ELF97 phosphate (ELFP) is a phosphatase substrate, which can produced a fluorescent, water-insoluble product ELF97 alcohol after hydrolysis by phosphatases. ELF97 phosphate can be utilized to study and quantify the activity of extracellular phosphatases of algae in natural water.

Luciferase-IN-4 (Compound 6b) is an inhibitor for luciferase with IC₅₀ of 4.1 μM. Luciferase-IN-4 inhibits purified luciferase in P. pyralis with IC₅₀ of 2.0 μM.

CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a K_i value of 216 nM. CDD-3290 also inhibits α-chymotrypsin and elastase.

MPC-IN-1 (compound 4i) is a cyanocinnamate-based, mitochondrial pyruvate transporter (MPC) inhibitor, and is a derivative of UK-5099 (HY-15475). MPC inhibitors promote the development of hair follicle stem cells without affecting normal cells. MPC-IN-1 promotes cellular lactate production and promotes significant hair growth in mice, and has the potential to be used to inhibit hair loss.

Isovaleryl-CoA sodium, a branched-chain acyl CoA, is a succinate:CoA ligase (SCL) inhibitor with an IC₅₀ of 273 μM in rat liver mitochondria.

DOTA-PEG4-alkyne TFA is a linker, and can be used for the labeling of radionuclide.

BCN-DOTA is a cyclooctyne-linked DOTA chelator. BCN-DOTA integrates BCN and DOTA, enabling conjugation with azide-functionalized groups via the click chemistry properties of BCN, while binding to metal ions through the coordination capacity of DOTA. BCN-DOTA can serve as a radionuclide-drug conjugate (RDC) to target specific biomolecules, cells or tissues after radiolabeling with zirconium-89. BCN-DOTA is applicable to research related to PET imaging and targeted therapy.

Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research.

TCO-PEG5-maleimide is a PEG linker with TCO and maleimide groups, specifically enabling tetrazine click chemistry and thiol conjugation for bioconjugation, probe design, and drug delivery.

PTAD-PEG8-alkyne is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

TANGO1-L Human scramble negative control is the scrambled negative control for TANGO1-L small interfering RNA.

1,2,3-Trilinoelaidoyl glycerol (TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E))) is a compound that affects dietary triolein and has an effect on the fatty acid composition of rat organs, prostaglandin biosynthesis and platelet function. Different doses of intake have different effects on related physiological parameters of rats.

1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol (1-Palmitin-2-stearin-3-olein), a compound used in the study of changes in diglyceride and triglyceride molecular species in cells, was analyzed by neutral loss mass spectrometry and its content was found to change after cell activation.

KAS 08 is an effective STING pathway activator in vitro and in vivo. KAS 08 enhances STING activity initiated by cGAMP.