2. Signaling Pathways
  3. Apoptosis
  4. DAPK
  5. DAPK1 Isoform
  6. DAPK1 Degrader

DAPK1 Degrader

DAPK1 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-179055
    PROTAC DAPK1 Degrader-1
    		Degrader
    PROTAC DAPK1 Degrader-1 (Compound CP1) is a DAPK1 PROTAC degrader with a DC50 of 119.6 nM. PROTAC DAPK1 Degrader-1 significantly increased the MDM2 protein level. PROTAC DAPK1 Degrader-1 significantly reduced the levels of cleaved caspase-3 and cleaved PARP in a cell apoptosis model induced by the neurotoxin ceramide, indicating that it effectively inhibits neuronal apoptosis by degrading DAPK1. PROTAC DAPK1 Degrader-1 can be used to study neurological diseases such as cerebral ischemia and traumatic brain injury (pink: DAPK1 ligand (HY-179071); blue: CRBN ligand (HY-10984); black: linker (HY-40171)).