DGK
Diacylglycerol kinase;
DGK (Diacylglycerol Kinase) modulates the balance between DAG and phosphatidic acid (PA). DGK phorylates DAG to generate PA. DGK has ten mammalian DGK subtypes (α-κ) with subtype-specific tissue distribution, and they can be classified into 5 types. Among them, DGKα and DGKζ specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell receptor. Whereas, DGKζ is the dominant isoform in T cells. Dysregulation of certain DGK isoforms leads to DAG-activation of PKC, attenuation of insulin signaling, and dysregulation of glucose metabolism. DGK plays a role in many physiological events, including cell proliferation and migration, glucose intake, immunity and neuronal network construction[1][2][3].
References:
- [1]. Riese MJ, et al. Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer. Front Cell Dev Biol. 2016 Oct 17;4:108. [Content Brief]
- [2]. Shirai Y, et al. Diacylglycerol kinase as a possible therapeutic target for neuronal diseases. J Biomed Sci. 2014 Apr 7;21(1):28. [Content Brief]
- [3]. Massart J, et al. Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis. Trends Endocrinol Metab. 2019 Sep;30(9):603-617. [Content Brief]
All Product Categories
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DGK Related Products (45)
Related Products (45)
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Antibodies (2)
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JNJ-3790339
0 ImagesCat. No.: HY-148174CAS No.: 93076-87-0JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation.
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DGKα-IN-7
0 ImagesCat. No.: HY-156577CAS No.: 2886092-50-6DGKα-IN-7 is a DGKα inhibitor with the IC50 of 6.225 nM, extracted from patent WO2022271684 (compound 100). DGKα-IN-7 has the potential for cancer study.
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INCB191358
0 ImagesCat. No.: HY-183539CAS No.: 3111036-70-2INCB191358 is a selective and orally active inhibitor of diacylglycerol kinase α/ζ/ι (DGKα/ζ/ι ) with IC50 values of 0.12, 0.36 and 0.36 nM. INCB191358 induces antigen-dependent T-cell activation, induces IL-2 production and enhances antitumor efficacy in combination with PD-1 blockade. INCB191358 can be used for the research of cancer, such as colon carcinoma.
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DGKζ-IN-6
0 ImagesCat. No.: HY-169317CAS No.: 3058005-75-4
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Dioctanoylglycol (Standard)
0 ImagesSynonyms: Ethylene glycol dicaprylate (Standard); Ethylene glycol dioctanoate (Standard); Ethylenedioctanoate (Standard); (Standard)Dioctanoylglycol (Standard) is the analytical standard of Dioctanoylglycol (HY-100960). This product is intended for research and analytical applications. Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (Ki of 58 μM).
