3111036-70-2
3111036-70-2
Chemical Structure
INCB191358
- CAS. Nr.: 3111036-70-2
- Formula:C25H30F3N5O3
- Molecular Weight:505.53
InChIKey: CWRMHWWCHYLSCJ-YSSFQJQWSA-N
SMILES: CC1=NC2=C(N1C[C@@H]3CCCO3)N(C(N=C2N4CC[C@@H](C[C@@H]4C)OC5=CC=C(C=C5)C(F)(F)F)=O)C
Biological Activity: INCB191358 is a selective and orally active inhibitor of diacylglycerol kinase α/ζ/ι (DGKα/ζ/ι ) with IC50 values of 0.12, 0.36 and 0.36 nM. INCB191358 induces antigen-dependent T-cell activation, induces IL-2 production and enhances antitumor efficacy in combination with PD-1 blockade. INCB191358 can be used for the research of cancer, such as colon carcinoma[1].
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INCB191358 | INCB191358 is a selective and orally active inhibitor of diacylglycerol kinase α/ζ/ι (DGKα/ζ/ι ) with IC50 values of 0.12, 0.36 and 0.36 nM. INCB191358 induces antigen-dependent T-cell activation, induces IL-2 production and enhances antitumor efficacy in combination with PD-1 blockade. INCB191358 can be used for the research of cancer, such as colon carcinoma. | |||||||||||||||||||||
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