2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Deubiquitinase
  5. USP15 Isoform
  6. USP15 Inhibitor

USP15 Inhibitor

USP15 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-180171
    USP11-IN-1
    		Inhibitor
    USP11-IN-1 (Compound 26) is a selective ubiquitin-specific protease 11 (USP11) inhibitor with an IC50 of 10.9 μM. USP11-IN-1 shows IC50 values of 18.1 and >500 μM for USP4 (SI = 1.7 fold) and USP15 (SI > 100 fold). USP11-IN-1 can be used for the research of USP11-related malignant tumors.
  • HY-184273
    TH-407a
    		Inhibitor
    TH-407a is an orally active and selective USP15 inhibitor with an IC50 of 0.76 μM. As an allosteric modulator, TH-407a binds to a non-catalytic site to block deubiquitinating activity. TH-407a inhibits cell growth, proliferation, clonogenicity and migration, regulates the p53 signaling pathway, and reduces the stability of PARP1. TH-407a exhibits anti-tumor activity in breast cancer xenograft mouse models. TH-407a can be used for the research of breast cancer.