1903103-73-0
Chemical Structure
TH-407a
- CAS No.: 1903103-73-0
- Formula:C22H18N4O
- Molecular Weight:354.40
InChIKey: KZAKDIOBPOOMII-UHFFFAOYSA-N
SMILES: [H]C1(CN(C(C2=CC=C3C(C=CC=C3)=C2)=O)C1)N4N=NC(C5=CC=CC=C5)=C4
Biological Activity: TH-407a is an orally active and selective USP15 inhibitor with an IC50 of 0.76 μM. As an allosteric modulator, TH-407a binds to a non-catalytic site to block deubiquitinating activity. TH-407a inhibits cell growth, proliferation, clonogenicity and migration, regulates the p53 signaling pathway, and reduces the stability of PARP1. TH-407a exhibits anti-tumor activity in breast cancer xenograft mouse models. TH-407a can be used for the research of breast cancer[1].
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TH-407a | TH-407a is an orally active and selective USP15 inhibitor with an IC50 of 0.76 μM. As an allosteric modulator, TH-407a binds to a non-catalytic site to block deubiquitinating activity. TH-407a inhibits cell growth, proliferation, clonogenicity and migration, regulates the p53 signaling pathway, and reduces the stability of PARP1. TH-407a exhibits anti-tumor activity in breast cancer xenograft mouse models. TH-407a can be used for the research of breast cancer. | |||||||||||||||||||||
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Keywords
