Glucokinase
Hexokinase IV; Hexokinase D
Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.
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Glucokinase Related Products (47)
Related Products (47)
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(S,S)-Sinogliatin
0 ImagesCat. No.: HY-119813CAS No.: 1191996-10-7Synonyms: (S,S)-HMS-5552; (S,S)-RO-5305552(S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes.
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PF-04991532 (Standard)
0 ImagesCat. No.: HY-100181RCAS No.: 1215197-37-7PF-04991532 (Standard) is the analytical standard of PF-04991532 (HY-100181). This product is intended for research and analytical applications. PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
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Glucokinase activator 8
0 ImagesCat. No.: HY-169545CAS No.: 349549-38-8Glucokinase activator 8 is an activator for glucokinase.
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GKA-71
0 ImagesCat. No.: HY-116682CAS No.: 863504-35-2GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.
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Glucokinase activator 11
0 ImagesCat. No.: HY-183490CAS No.: 1263402-76-1Glucokinase activator 11 is a substituted benzamide derivative and glucokinase activator. Glucokinase activator 11 can be used for the research of type ii diabetes.
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Glucokinase activator 5
0 ImagesCat. No.: HY-156923CAS No.: 536736-95-5Glucokinase activator 5 (compound 6) is a glucokinase activator.
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PSN-GK1
0 ImagesCat. No.: HY-U00411CAS No.: 745051-61-0PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.
