Glucokinase
Hexokinase IV; Hexokinase D
Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.
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Glucokinase Related Products (47)
Related Products (47)
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MK-0941 free base
0 ImagesCat. No.: HY-19843ACAS No.: 752240-01-0MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
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AR453588 hydrochloride
0 ImagesCat. No.: HY-133127ACAS No.: 1065606-97-4AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.
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Glucokinase activator 1
0 ImagesCat. No.: HY-101788CAS No.: 1328987-85-4Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
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Glucokinase activator 6
0 ImagesCat. No.: HY-116946CAS No.: 480463-02-3Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC50 of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.
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CM-10-18
0 ImagesCat. No.: HY-117603CAS No.: 1159614-57-9
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ADP-Specific glucokinase, thermococcus litoralis
0 ImagesCat. No.: HY-P3257BSynonyms: ADP-Dependent hexokinase, thermococcus litoralisADP-Specific glucokinase, thermococcus litoralis is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, thermococcus litoralis can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, thermococcus litoralis can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, thermococcus litoralis can be used in research on metabolic diseases, neurological disorders, and tumors.
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LCZ960
0 ImagesCat. No.: HY-177297CAS No.: 1067877-83-1Synonyms: NVP-LCZ960LCZ960 is an orally active glucokinase (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO). LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes.
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NVP-LBX192
0 ImagesCat. No.: HY-14172CAS No.: 866772-52-3NVP-LBX192 (Compound 17c) is a glucokinase activator with a K(a) of 39 nM. NVP-LBX192 can significantly reduce glucose levels. NVP-LBX192 can be used for the research of metabolic disease, such as type 2 diabetes.
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ADP-specific glucokinase, pyrococcus furiosus
0 ImagesCat. No.: HY-P3257ACAS No.: 173585-07-4Synonyms: ADP-dependent hexokinase, pyrococcus furiosusADP-Specific glucokinase, pyrococcus furiosus is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, pyrococcus furiosus can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, pyrococcus furiosus can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, pyrococcus furiosus can be used in research on metabolic diseases, neurological disorders, and tumors.
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AZD1092
0 ImagesCat. No.: HY-121070CAS No.: 871656-65-4AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).
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RO-4597014
0 ImagesCat. No.: HY-19494CAS No.: 710321-76-9RO-4597014 is a glucokinase inhibitor. RO-4597014 can be used in the study of diabetes.
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PF-04279405
0 ImagesCat. No.: HY-136631CAS No.: 955881-01-3PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM). Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes.
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Glucolipsin B
0 ImagesCat. No.: HY-N14597CAS No.: 222613-93-6Glucolipsin B is a glucokinase activator.
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Glucokinase activator 7
0 ImagesCat. No.: HY-W997026CAS No.: 66780-67-4Glucokinase activator 7 is a Glucokinase activator. Glucokinase activator 7 can be used for research of diabetes, hyperglycemia and other diseases (Compound in Page 176 of Ref.).
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Piragliatin
0 ImagesCat. No.: HY-14747CAS No.: 625114-41-2Synonyms: RO4389620Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy.
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Nerigliatin (Standard)
0 ImagesSynonyms: PF-04937319 (Standard)Nerigliatin (Standard) is the analytical standard of Nerigliatin. This product is intended for research and analytical applications. Nerigliatin (PF-04937319) is a orally active glucokinase activator (GKA) with EC50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research.
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AM-2394 (Standard)
0 ImagesCat. No.: HY-100221RCAS No.: 1442684-77-6AM-2394 (Standard) is the analytical standard of AM-2394 (HY-100221). This product is intended for research and analytical applications. AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
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Glucokinase activator 10
0 ImagesCat. No.: HY-179419Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active glucokinase activator with an EC50 of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders.
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Glucolipsin A
0 ImagesCat. No.: HY-N14596CAS No.: 222613-92-5Glucolipsin A is a glucokinase activator.
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RO-28-1675 (Standard)
0 ImagesCat. No.: HY-10595RCAS No.: 300353-13-3RO-28-1675 (Standard) is the analytical standard of RO-28-1675 (HY-10595). This product is intended for research and analytical applications. RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.
