2. Signaling Pathways
  3. Immunology/Inflammation
  4. IRAK
  5. IRAK1 Isoform
  6. IRAK1 Degrader

IRAK1 Degrader

IRAK1 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-153188
    JNJ-1013
    		Degrader 99.80%
    JNJ-1013 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis.html" class="link-product" target="_blank">Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705).