LIM Kinase (LIMK) Inhibitor

MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research.

TL13-68 is a biotin-tagged version of SM1-71, and it can be used to research the mechanism of SM1-71.

S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with the IC₅₀ of 9 μM.

LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC₅₀ values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer.

Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM.

Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer.

LIMK2 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.

Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers.

Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.