CRT 0105446
CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM.
For research use only. We do not sell to patients.
- CAS No.: 1661846-05-4
- Formula: C20H18F3N3O2S
- Molecular Weight:421.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
0.008 μM
Compound: 22d
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Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrate
Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrate
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[PMID: 26356364] |
| ZR-75-1 | IC50 |
2 μM
Compound: 22d
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Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs
Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs
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[PMID: 26356364] |
CRT 0105446 (compound 22d) inhibits the invasion of the cells through matrigel at a concentration of 3 µM, whilst not significantly affecting cell viability even at the higher compound concentration of 10 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1661846-05-4
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Molecular Weight 421.44
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Formula C20H18F3N3O2S
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SMILES
CC(C(NC1=NC=C(S1)C2=C(C=NC=C2)C3=CC=C(C=C3C(F)(F)F)OC)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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