LIMK-IN-2
LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.
For research use only. We do not sell to patients.
- CAS No.: 2747216-27-7
- Formula: C28H27N5O2
- Molecular Weight:465.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | EC50 |
>25 μM
Compound: 52
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Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis
Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis
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[PMID: 38669909] |
| HeLa | EC50 |
26 μM
Compound: 52
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Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay
Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay
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[PMID: 38669909] |
| KHOS/NP | IC50 |
6.2 μM
Compound: 52
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Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis
Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis
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[PMID: 38669909] |
| U2OS | IC50 |
9.5 μM
Compound: 52
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Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay
Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay
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[PMID: 38669909] |
Chemical Information
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CAS No. 2747216-27-7
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Molecular Weight 465.55
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Formula C28H27N5O2
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SMILES
COC1=CC=CC(C2=CC(NC(N3CCC(C4=C5C(NC=C5C6CC6)=NC=N4)=CC3)=O)=CC=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LIMK-IN-2 Related Classifications
HY-161417 Related Classifications
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