PGC-1α Agonist
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MARY1
0 ImagesCat. No.: HY-174306MARY1 is a selective 5-HT2BR antagonist with an IC50 of 380 nM and a Ki of 764 nM (human 5-HT2BR). MARY1 induces renal mitochondrial biogenesis (MB) and enhances renal mitochondrial function by increasing mitochondrial respiratory capacity, mitochondrial protein levels, and mitochondrial number in renal proximal tubular cells (RPTCs). MARY1 induces MB through 5-HT2BR and dual PI3K/AKT and RAS/MEK/ERK cell signaling pathways in RPTCs. MARY1 can be used to study renal diseases associated with metabolic and mitochondrial dysfunction.
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PPARγ agonist-24
0 ImagesCat. No.: HY-184323PPARγ agonist-24 is a peroxisome proliferator-activated receptor gamma agonist with oral effectiveness, a PPARγ IC50 of 1.752 μM, and a PPARγ Ki of 54.81 nM. PPARγ agonist-24 shows higher selectivity toward PPARγ than PPARα and weak activity toward PPARδ. PPARγ agonist-24 enhances PPARγ protein expression in hepatic cells. PPARγ agonist-24 can be used for the research of type 2 diabetes (t2dm).
