Plasmodium
Plasmodium parasites invade erythrocytes to access nutrients and occupy a protected intracellular niche[1]. Mechanistically, P. falciparum merozoite invasion depends on ligand-receptor interactions and regulated microneme and rhoptry secretion[2]. The apicoplast supports blood-stage growth mainly through isoprenoid precursor biosynthesis, shown by chemical rescue of parasites lacking this organelle[3]. Apicoplast-derived isoprenoids also support GPI-anchor biosynthesis, egress, and invasion in P. falciparum[4]. Compared with related apicomplexan parasites, malaria parasites use conserved host-cell entry logic but species-specific ligand-receptor interactions[1]. For experimental applications, apicoplast translation inhibitors and aminoacyl-tRNA synthetase inhibitors provide tools to test delayed death, organelle maintenance, and parasite viability[5][6].
References:
- [1]. Cowman AF, et al. Invasion of red blood cells by malaria parasites. Cell. 2006 Feb 24;124(4):755-66. [Content Brief]
- [2]. Singh S, et al. Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites. PLoS Pathog. 2010 Feb 5;6(2):e1000746. [Content Brief]
- [3]. Yeh E, et al. Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. PLoS Biol. 2011 Aug;9(8):e1001138. [Content Brief]
- [4]. Bulloch MS, et al. Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum. PLoS Pathog. 2024 Sep 6;20(9):e1012484. [Content Brief]
- [5]. Pasaje CF, et al. Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum. Sci Rep. 2016 Jun 9;6:27531. [Content Brief]
- [6]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77. [Content Brief]
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Plasmodium Related Products (265)
Related Products (265)
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Rac1-IN-6
0 ImagesCat. No.: HY-181864CAS No.: 2310304-72-2Rac1-IN-6 (Compound 5e) is a selective Rac1 inhibitor and antimalarial agent. Rac1-IN-6 inhibits Rac1 activation induced by the Escherichia coli CNF1 toxin. Rac1-IN-6 suppresses the growth of chloroquine-sensitive Plasmodium falciparum D10 (IC50 = 76.0 nM) and chloroquine-resistant Plasmodium falciparum W2 (IC50 = 236.6 nM).
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Ambigol C
0 ImagesCat. No.: HY-N18878CAS No.: 850655-31-1Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections.
