ROR
RAR-related orphan receptor
Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and belonging to the orphan nuclear receptor family. The ROR subfamily contains three members: RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) and function as ligand-dependent transcription factors.
RORs are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis.
RORα and RORγ are important regulators of the immune system. The development and differentiation of Th17 cells are dependent on these factors. RORγ is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and γδ T cells, which contribute to inflammation and autoimmune disease.
ROR Isoform Specific Products
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ROR Inhibitors
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ROR Agonists
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ROR Antagonists
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ROR Activators
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ROR Modulators
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ROR Inducer
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ROR Degraders
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ROR Control
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ROR Ligands
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ROR Related Products (148)
Related Products (148)
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Antibodies (5)
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ROR Isoform Comparison
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TMP780
0 ImagesTMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders.
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3-Oxo-5β-cholanoic acid (Standard)
0 ImagesSynonyms: Dehydrolithocholic acid (Standard); 3-oxoLCA (Standard)3-Oxo-5β-cholanoic acid (Standard) is the analytical standard of 3-Oxo-5β-cholanoic acid. This product is intended for research and analytical applications. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].
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RORγt agonist 2
0 ImagesCat. No.: HY-142937CAS No.: 2663787-92-4RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 2 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136339A1, compound 17).
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RORγt/DHODH-IN-1
0 ImagesCat. No.: HY-142843CAS No.: 2764662-15-7RORγt/DHODH-IN-1 (compound (R)-14d) is a potent and orally active dual RORγt/DHODH inhibitor, with IC50s of 0.083 μM and 0.172 μM, respectively. RORγt/DHODH-IN-1 exhibits remarkable in vivo anti-inflammatory activity.
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RORγt modulator 2
0 ImagesCat. No.: HY-142935CAS No.: 2247083-47-0RORγt modulator 2 (Compound 21) is a modulator of retinoid-related orphan receptor γt (RORγt) with the IC50 of <50 nM. RORγt modulator 2 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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Methyl-3β-hydroxycholenate
0 ImagesCat. No.: HY-100084CAS No.: 20231-57-6Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
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RORγt inverse agonist 28
0 ImagesCat. No.: HY-142703CAS No.: 2741870-21-1RORγt inverse agonist 28 is a potent reverse agonist of RORγt. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 6) .
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RORγt modulator 4
0 ImagesCat. No.: HY-142939CAS No.: 2188177-73-1RORγt modulator 4 is a RORγt modulator. RORγt modulator 4 has an activity to modulate IL-17A production in cells derived from mouse spleen (WO2018030550A1; compound 146).
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RORγt/DHODH-IN-3
0 ImagesCat. No.: HY-142847CAS No.: 2764662-16-8RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity.
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Rorc Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12133Rorc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rorc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Rora Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12127Rora Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rora gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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RORγt/DHODH-IN-2
0 ImagesCat. No.: HY-142834CAS No.: 2641758-86-1RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research.
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Allolithocholic acid (Standard)
0 ImagesCat. No.: HY-143712RCAS No.: 2276-94-0Allolithocholic acid (Standard) is the analytical standard of Allolithocholic acid (HY-143712). This product is intended for research and analytical applications. Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
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RORγ inverse agonist 2
0 ImagesCat. No.: HY-175490CAS No.: 1242610-59-8
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JNJ-54119936
0 ImagesCat. No.: HY-148237CAS No.: 1599531-55-1JNJ-54119936, a chemical probe, is a RORγ (RORc) inverse agonist (Kd=5.3 nM).
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RORγt modulator 3
0 ImagesCat. No.: HY-142936CAS No.: 2230877-38-8RORγt modulator 3 (Compound 23) is a modulator of retinoid-related orphan receptor γt (RORγt). RORγt modulator 3 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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RORγt inhibitor 4
0 ImagesCat. No.: HY-19510CAS No.: 1426803-07-7RORγt inhibitor 4 (Compound 9a) is an orally active and a CNS-penetrating RORγt inhibitor. RORγt inhibitor 4 improves experimental autoimmune encephalomyelitis.
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TF-S14
0 ImagesCat. No.: HY-162490CAS No.: 2425563-60-4
