2425563-60-4
2425563-60-4
Chemical Structure
TF-S14
- CAS No.: 2425563-60-4
- Formula:C22H27N3O2S
- Molecular Weight:397.53
InChIKey: PCTBZMHJFHFNAH-HUUCEWRRSA-N
SMILES: O=C(N1CC[C@@H](C)C[C@H]1C)C2=C(NC(C3=CN=CC=C3)=O)SC4=C2CCCC4
Biological Activity: TF-S14 is a reverse agonist of RORγt. TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation[1].
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TF-S14 | TF-S14 is a reverse agonist of RORγt. TF-S14 reduces Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22 by binding to and inhibiting RORγt activity. TF-S14 can be used in the study of autoimmune diseases and rejection in allotransplantation. | |||||||||||||||||||||
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References
Keywords
