Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
-
Sodium Channel
(627)
View all products
-
Nav1.1
(11)
View all products
-
Nav1.2
(16)
View all products
-
Nav1.3
(14)
View all products
-
Nav1.4
(14)
View all products
-
Nav1.5
(21)
View all products
-
Nav1.6
(12)
View all products
-
Nav1.7
(61)
View all products
-
Nav1.8
(41)
View all products
-
Nav1.9
(2)
View all products
All Product Categories
-
Sodium Channel Inhibitors
(619)
View all products
-
Sodium Channel Agonists
(10)
View all products
-
Sodium Channel Antagonists
(30)
View all products
-
Sodium Channel Activators
(35)
View all products
-
Sodium Channel Modulators
(28)
View all products
-
Sodium Channel Controls
(5)
View all products
-
Sodium Channel Ligands
(3)
View all products
-
Sodium Channel Related Products (800)
Related Products (800)
-
Antibodies (9)
-
Related Compound Screening Libraries (1)
-
Sodium Channel Isoform Comparison
-
Indecainide hydrochloride
0 ImagesCat. No.: HY-16259CAS No.: 73681-12-6Synonyms: Ricainide hydrochloride; LY 135837Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na+-channel-blocking activity.
-
Nav1.5-IN-1
0 ImagesCat. No.: HY-181063CAS No.: 899207-91-1Nav1.5-IN-1 is a selective Nav1.5 inhibitor with an IC50 of 1.38 μM. Nav1.5-IN-1 shows selectivity over other Nav subtypes. Nav1.5-IN-1 reduces cardiac conduction in isolated rat hearts.Nav1.5-IN-1 can be used for the research of arrhythmias.
-
Mepivacaine-d3
0 ImagesMepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
-
Ranolazine-d5
0 ImagesCat. No.: HY-B0280SCAS No.: 1092804-87-9Synonyms: CVT 303-d5; RS 43285-003-d5Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
-
Nav1.8-IN-7
0 ImagesCat. No.: HY-160588CAS No.: 2761181-58-0Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.
-
6-Iodoamiloride
0 ImagesCat. No.: HY-155017CAS No.: 60398-23-46-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM.
-
ICI 147798
0 ImagesCat. No.: HY-182635CAS No.: 83812-65-1ICI 147798 is an orally effective β-adrenoceptor antagonist with a pKB of 9.1 (in guinea pig right atrium) and 8.8 (in guinea pig trachea). ICI 147798 acts as a diuretic and intraocular pressure-lowering agent. ICI 147798 blocks β-adrenoceptors, inhibits isoproterenol-induced tachycardia and vasodepressor responses, exhibits slowly dissociating, insurmountable antagonism against β1-adrenoceptors, and shows surmountable competitive antagonism against β2-adrenoceptors. ICI 147798 induces natriuresis and kaliuresis, inhibits sodium transport, and reduces intraocular pressure.
-
Fluphenazine dihydrochloride (Standard)
0 ImagesFluphenazine (dihydrochloride) (Standard) is the analytical standard of Fluphenazine (dihydrochloride). This product is intended for research and analytical applications. Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
-
Atomoxetine-d7 hydrochloride
0 ImagesCat. No.: HY-17385S1Synonyms: Tomoxetine-d7 hydrochloride; (R)-Tomoxetine-d7 hydrochlorideAtomoxetine-d7 hydrochloride (Tomoxetine-d7 hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
-
Pramocaine-d9 hydrochloride
0 ImagesCat. No.: HY-B1319S1Synonyms: Pramoxine-d9 hydrochloridePramocaine-d9 (Pramoxine-d9) hydrochloride is the d9-labeled Pramocaine hydrochloride (HY-B1319). Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
-
BDF 9148
0 ImagesCat. No.: HY-116119CAS No.: 120838-62-2BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure.
-
PptT-IN-4
0 ImagesCat. No.: HY-149305CAS No.: 2948309-57-5PptT-IN-4 (Compound 3a) is a PptT inhibitor (IC50: 0.71 μM). PptT-IN-4 inhibits Mtb H37Rv with a MIC value of 42 μM. PptT-IN-4 also inhibits hERG, hCav1.2, and hNav1.5 channels with IC50s of 11 μM, 8.1 μM, 6.9 μM respectively.
-
E-0747
0 ImagesCat. No.: HY-106749CAS No.: 99599-78-7E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes.
-
Ethacizine
0 ImagesCat. No.: HY-131987CAS No.: 33414-33-4Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.
-
Leporin A
0 ImagesCat. No.: HY-N16421CAS No.: 140381-54-0Leporin A is an insecticide. Leporin A binds to GABA receptors or sodium channels to disrupt neurotransmission.
-
5-HT2C-agonist-14
0 ImagesCat. No.: HY-183652CAS No.: 3091546-67-45-HT2C-agonist-14 is a 5-HT2C receptor agonist with an EC50 of 2.9 μM against human receptors. It also acts as a voltage-gated sodium channel inhibitor with blood-brain barrier permeable. 5-HT2C-agonist-14 elevates seizure threshold, suppresses seizure progression and alleviates pain-related behaviors. It can be used in the research of epilepsy and pain-related diseases.
-
Halofuginone hydrochloride (Standard)
0 ImagesCat. No.: HY-N1584BRCAS No.: 1217623-74-9Synonyms: RU-19110 hydrochloride (Standard)Halofuginone hydrochloride (Standard) (RU-19110 hydrochloride (Standard)) is the analytical standard of Halofuginone hydrochloride (HY-N1584B). This product is intended for research and analytical applications. Halofuginone hydrochloride (RU-19110 hydrochloride), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrochloride is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrochloride is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrochloride has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
