2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. μ-TRTX-Hd1a

μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II.

For research use only. We do not sell to patients.

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μ-TRTX-Hd1a Chemical Structure

μ-TRTX-Hd1a Chemical Structure

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μ-TRTX-Hd1a Related Antibodies

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Description

μ-TRTX-Hd1a, a spider venom, is a selective NaV 1.7 inhibitor. μ-TRTX-Hd1a is a gating modifier that inhibits human NaV 1.7 by interacting with the S3b-S4 paddle motif in channel domain II[1].

Molecular Weight

3822.33

Formula

C160H246N46O51S6
Sequence

Ala-Cys-Leu-Gly-Phe-Gly-Lys-Ser-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Ser-Leu-Ala-Cys-Ser-Thr-Lys-His-Lys-Trp-Cys-Lys-Tyr-Glu-Leu (Disulfide bridge:Cys2-Cys17;Cys9-Cys24;Cys16-Cys31)
Sequence Shortening

ACLGFGKSCNPSNDQCCKSSSLACSTKHKWCKYEL (Disulfide bridge:Cys2-Cys17;Cys9-Cys24;Cys16-Cys31)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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μ-TRTX-Hd1a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

μ-TRTX-Hd1aSodium ChannelNa channelsNa+ channelsNaV 1.7 inhibitorspider venomS3b-S4 paddle motifInhibitorinhibitorinhibit

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