Nav1.8-IN-7
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.
For research use only. We do not sell to patients.
- CAS No.: 2761181-58-0
- Formula: C22H18ClF4N3O5
- Molecular Weight:515.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Nav1.8-IN-9 (Example 116; 1 μM) shows inhibitions of 1.2％, 3.7％, <1％, <1％, 2.6％, <1％ for Nav1.1, Nav1.3, Nav1.4, Nav1.5, Nav1.6, and Nav1.7, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
| PO (100 mg/kg) | |
| Cmax (ng/mL) | 2566 |
| AUC0-24 (ng/mL∗h) | 42454 |
| t1/2 (h) | 8.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2761181-58-0
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Molecular Weight 515.84
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Formula C22H18ClF4N3O5
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SMILES
OC[C@@H](O)COC1=CC(NC(C(C=C(C(C(F)(F)F)=C2)Cl)=C2OC3=C(C=C(C=C3)F)C)=O)=CN=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vivo:
The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nav1.8-IN-7 Related Classifications
HY-160588 Related Classifications
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