Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
-
Beta-lactamase Related Products (254)
Related Products (254)
-
Beta-lactamase Isoform Comparison
-
(S)-2-Benzylsuccinic acid
0 ImagesCat. No.: HY-W002684CAS No.: 3972-36-9(S)-2-Benzylsuccinic acid is an intermediate of KAD-1229 (HY-B0682A). (S)-2-Benzylsuccinic acid exerts weak inhibitory activity against IMP-1 metallo-β-lactamase.
-
Eravacycline
0 ImagesCat. No.: HY-16980CAS No.: 1207283-85-9Synonyms: TP-434Eravacycline is a potent and broad-spectrum antibacterial agent.
-
Cefditoren sodium
0 ImagesCat. No.: HY-17452CAS No.: 104146-53-4Synonyms: ME 1206Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
-
Dicloxacillin
0 ImagesDicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus.
-
Nafcillin
0 ImagesNafcillin, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin exhibits bactericidal activity, and can be used for the research of staphylococcal infections.
-
FPI-1523
0 ImagesCat. No.: HY-139745ACAS No.: 1452459-50-5FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity.
-
BLI-489
0 ImagesCat. No.: HY-108062CAS No.: 623564-40-9BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens.
-
NDM-1 inhibitor-3
0 ImagesNDM-1 inhibitor-3 (Compound 89) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a Ki of 4 μM.
-
IMB-XH1
0 ImagesIMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively.
-
Thiamphenicol (Standard)
0 ImagesSynonyms: Thiophenicol (Standard); Dextrosulphenidol (Standard)Thiamphenicol (Standard) is the analytical standard of Thiamphenicol. This product is intended for research and analytical applications. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria).
-
Ciprofloxacin prodrug-1
0 ImagesCat. No.: HY-177716CAS No.: 2418537-98-9Ciprofloxacin prodrug-1 (Compound 35) is an activated prodrug of β-lactase. Ciprofloxacin prodrug-1 exhibits good antibacterial activity against bacteria containing β-lactase (MIC = 63 nM). After being hydrolyzed by β-lactase, Ciprofloxacin prodrug-1 can release Ciprofloxacin (HY-B0356), thereby inhibiting the activity of DNA gyrase. Ciprofloxacin prodrug-1 can be used to study infections caused by enzyme-producing drug-resistant bacteria (such as uropathogenic Escherichia coli).
-
K-252c
0 ImagesK-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.
-
Tazobactam (Standard)
0 ImagesSynonyms: CL-298741 (Standard); YTR-830H (Standard)Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
-
Ceftibuten
0 ImagesCat. No.: HY-B0698CAS No.: 97519-39-6Synonyms: Sch 39720Ceftibuten (Sch39720), an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens.
-
Penicillin G sodium salt (Standard)
0 ImagesPenicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.
