2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14879C
    Avibactam sodium dihydrate
    		Inhibitor
    Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
    Avibactam sodium dihydrate
  • HY-120859A
    Zidebactam sodium salt
    		Inhibitor
    Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL.
    Zidebactam sodium salt
  • HY-136070
    Xeruborbactam bis-acetoxy methyl ester
    		Inhibitor
    Xeruborbactam bis-acetoxy methyl ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 42.
    Xeruborbactam bis-acetoxy methyl ester
  • HY-105246
    Pracinostat dihydrochloride
    		Inhibitor
    Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM.
    Pracinostat dihydrochloride
  • HY-138247R
    β-Lactamase-IN-2 (Standard)
    		Inhibitor
    ATP (disodium salt) (Standard) is the analytical standard of ATP (disodium salt). This product is intended for research and analytical applications. ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
    β-Lactamase-IN-2 (Standard)
  • HY-125356
    ETX0282
    		Inhibitor
    ETX0282 is an orally active prodrug, with its active form being ETX1317. ETX0282 and ETX1317 are β-lactamase inhibitors of the dioxolane-dibenzo-p-heptane (DBO) type. ETX0282 exhibits high stability during intestinal absorption and can be efficiently converted into ETX1317 in the liver. ETX0282 alone has no bactericidal activity, but in a mouse model of neutropenic thigh infection, it can significantly reduce bacterial load when used in combination with Cefpodoxime Proxetil (HY-N7101). ETX0282 can be used for the study of infections caused by drug-resistant Gram-negative bacteria.
    ETX0282
  • HY-B0466A
    Cloxacillin
    		Inhibitor
    Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 µM. Cloxacillin can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin
  • HY-B0698B
    Ceftibuten monohydrate
    		Inhibitor
    Ceftibuten (Sch39720) monohydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens.
    Ceftibuten monohydrate
  • HY-168500
    Metallo-β-lactamase-IN-16
    		Inhibitor
    Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively.
    Metallo-β-lactamase-IN-16
  • HY-144259
    Metallo-β-lactamase-IN-2
    		Inhibitor
    Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively.
    Metallo-β-lactamase-IN-2
  • HY-105914
    OCA 983
    		Inhibitor
    OCA 983 is an orally active tetrahydrofuranyl 1β-methylcarbapenem antibiotic. OCA 983 exhibits potent inhibitory activity against class A and class C β-lactamases. OCA 983 possesses a broad antibacterial spectrum, and can be used in the research of infectious diseases.
    OCA 983
  • HY-120876
    L-680833
    		Inhibitor
    L-680833 is a monocyclic β-lactam inhibitor of human polymorphonuclear leukocyte elastase (PMNE) inhibitor. L-680833 can be used for the study of PMNE-damaged tissue diseases.
    L-680833
  • HY-W588257
    (+)-Thienamycin
    		Inhibitor
    (+)-Thienamycin is a potent broad-spectrum antibacterial and β-lactamase inhibitor that can be from Streptomyces cattleya.
    (+)-Thienamycin
  • HY-Z14061
    Doxazosin impurity 12
    		Inhibitor
    Doxazosin impurity 12 is a CTX-Mβ-lactamase inhibitor, with a Ki value of 0.7 mM for CTX-M.
    Doxazosin impurity 12
  • HY-162174
    MBL-IN-2
    		Inhibitor
    MBL-IN-2 ((2R, 2R')-5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC50 of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used for the study of resistance to β-lactam antibiotics.
    MBL-IN-2
  • HY-149929
    EBL-3183
    		Inhibitor
    EBL-3183, an indole-2-carboxylate, is a potent metallo-β-lactamase (MBL) inhibitor. EBL-3183 is reversibly binding, non-covalent, competitive NDM-1 inhibitor with a pIC50 of 7.7.
    EBL-3183
  • HY-136071
    Xeruborbactam methoxy acetoxy methy ester
    		Inhibitor
    Xeruborbactam methoxy acetoxy methy ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 43.
    Xeruborbactam methoxy acetoxy methy ester
  • HY-163339
    Metallo-β-lactamase-IN-14
    		Inhibitor
    Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa.
    Metallo-β-lactamase-IN-14
  • HY-B0555B
    Nafcillin sodium
    		Inhibitor
    Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections.
    Nafcillin sodium
  • HY-163338
    Metallo-β-lactamase-IN-13
    		Inhibitor
    Metallo-β-lactamase-IN-13 (Compound 13i) is a pan Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa.
    Metallo-β-lactamase-IN-13
Beta-lactamase Isoform Comparison

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