Thiomandelic acid

Cat. No.: HY-129629 Purity: 95.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases.

For research use only. We do not sell to patients.

Thiomandelic acid Chemical Structure

CAS No. : 4695-09-4

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Metallo-β-lactamase

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thiomandelic acid is a broad spectrum inhibitor of Zinc -lactamases^[1].

In Vitro

Thiomandelic acid is found to be a reasonably potent (submicromolar) inhibitor for all of the MBLs tested, except for the subclass B2 enzyme from A. hydrophila (CphA)^[1].
Thiomandelic Acid binds to both metal ions in metallo-β-lactamase and induces positive cooperativity in metal binding^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

168.21

Formula

C₈H₈O₂S

CAS No.

4695-09-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(S)C1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1486.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9449 mL	29.7247 mL	59.4495 mL
5 mM	1.1890 mL	5.9449 mL	11.8899 mL
10 mM	0.5945 mL	2.9725 mL	5.9449 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.37%

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Data Sheet (272 KB) SDS (0 KB)

COA (248 KB) HNMR (262 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. C Mollard, et al. Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. J Biol Chem. 2001 Nov 30;276(48):45015-23. [Content Brief]

[2]. Christian Damblon, et al. The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding. J Biol Chem. 2003 Aug 1;278(31):29240-51. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.9449 mL	29.7247 mL	59.4495 mL	148.6237 mL
	5 mM	1.1890 mL	5.9449 mL	11.8899 mL	29.7247 mL
	10 mM	0.5945 mL	2.9725 mL	5.9449 mL	14.8624 mL
	15 mM	0.3963 mL	1.9816 mL	3.9633 mL	9.9082 mL
	20 mM	0.2972 mL	1.4862 mL	2.9725 mL	7.4312 mL
	25 mM	0.2378 mL	1.1890 mL	2.3780 mL	5.9449 mL
	30 mM	0.1982 mL	0.9908 mL	1.9816 mL	4.9541 mL
	40 mM	0.1486 mL	0.7431 mL	1.4862 mL	3.7156 mL
	50 mM	0.1189 mL	0.5945 mL	1.1890 mL	2.9725 mL
	60 mM	0.0991 mL	0.4954 mL	0.9908 mL	2.4771 mL
	80 mM	0.0743 mL	0.3716 mL	0.7431 mL	1.8578 mL
	100 mM	0.0594 mL	0.2972 mL	0.5945 mL	1.4862 mL