2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutaminase
  5. Glutaminase Antagonist

Glutaminase Antagonist

Glutaminase Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-108357
    6-Diazo-5-oxo-L-nor-Leucine
    		Antagonist 99.95%
    6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity.
  • HY-122218
    JHU-083
    		Antagonist ≥98.0%
    JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.