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Cat. No.: HY-P3169

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a-Helical Corticotropin Releasing Factor (9-41)

Name: a-Helical Corticotropin Releasing Factor (9-41)
Brand: MedChemExpress
SKU: HY-P3169
Price: 437.00 USD
Availability: InStock
Rating: 5 (1 reviews)

α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo.

For research use only. We do not sell to patients.

CAS No.: 99658-03-4
Formula: C₁₆₆H₂₇₃N₄₅O₅₄S₂
Molecular Weight:3827.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

a-Helical Corticotropin Releasing Factor (9-41) Chemical Structure

CAS No.: 99658-03-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
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Classifications
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Biological Activity

Description

All CRFR Isoforms :

CRFR1
CRFR2

In Vivo

α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values^[1].
α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult Sprague-Dawley rats^[1]
Dosage:

10 μg
Administration:

The third or lateral ventricle of the brain injection; 10 μg once
Result:

Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress.

Animal Model:

Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)^[1]
Dosage:

10 μg
Administration:

Lateral ventricle brain injection; 10 μg once
Result:

Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF).

Animal Model:

Male Wistar rats with rhlL-1/β injection^[2]
Dosage:

100 ng/kg
Administration:

Intracerebroventricularly injection; 100 ng/kg once
Result:

Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β.

Chemical Information

CAS No. 99658-03-4
Molecular Weight 3827.34
Formula C₁₆₆H₂₇₃N₄₅O₅₄S₂
Sequence Shortening

DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rivier C, Vale W. Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology. 1985 Dec;117(6):2478-82. [Content Brief]

[2]. Takakazu Oka, et al. Intracerebroventricular injection of interleukin-1/β induces hyperalgesia in rats. Brain Research, 624 (1993) 61-68.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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a-Helical Corticotropin Releasing Factor (9-41)

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a-Helical Corticotropin Releasing Factor (9-41)

All CRFR Isoforms

Biological Activity

Description

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

a-Helical Corticotropin Releasing Factor (9-41) Related Classifications

HY-P3169 Related Classifications

Bioz

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