2. GPCR/G Protein
  3. CRFR
  4. CP 316311

CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

For research use only. We do not sell to patients.

CP 316311 Chemical Structure

CP 316311 Chemical Structure

CAS No. : 175139-41-0

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CP 316311 Related Antibodies

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Description

CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.

IC50 & Target

IC50: 6.8 nM (CRF1 receptor)[1]
In Vitro

CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP 316311 Related Antibodies
In Vivo

CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic−pituitary−adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

327.46

Formula

C21H29NO2
CAS No.
SMILES

CCC(CC)OC1=C(C)C(OC2=C(C)C=C(C)C=C2C)=NC(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP 316311 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 316311175139-41-0CP316311CP-316311CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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HY-14129
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