Anti-Mouse Vβ4 TCR Antibody (KT4)
Anti-Mouse Vβ4 TCR Antibody (KT4) is an anti-mouse Vβ4 TCR IgG2b monoclonal antibody. Anti-Mouse Vβ4 TCR Antibody (KT4) can reduce the proportion of Vβ4+ T cells without affecting their function. Anti-Mouse Vβ4 TCR Antibody (KT4) can be used for research on immunology and infection conditions such as virus infection. Anti-Mouse Vβ4 TCR Antibody (KT4) is often used in flow cytometry.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2b
Recommend Isotype Controls
Species Reactivity
Mouse
In Vivo
Anti-Mouse Vβ4 TCR Antibody (KT4) (300 μg, i.p., once every 3 days, for 10 days) reduces the proportion of Vβ4+ T cells but does not affect their function in C57BL/6 mice with a MHV68 virus injection model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×105 PFU MHV68 virus injected C57BL/6 mice (6-12 weeks)[1]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), on day 4 and day 2 before infection, on the day of infection, and once a week after infection
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Result:Caused depletion of Vβ4+ T cells but failed to improve transplant rejection.
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Animal Model:1×103 PFU MHV68 virus injected C57BL/6 mice (8-14 weeks)[2]
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Dosage:300 μg
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Administration:Intraperitoneal injection (i.p.), once every 3 days, for 10 days
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Result:Reduced the proportion of Vβ4+ T cells.
Did not affect the production of IFNγ.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo administration; Flow cytometry
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse Vβ4 TCR Antibody (KT4)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Beus JM, et al. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. PLoS One. 2013 Aug 5;8(8):e71221. [Content Brief]
[2]. Evans AG, et al. A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. J Exp Med. 2008 Mar 17;205(3):669-84. [Content Brief]
[3]. Launois P, et a;. Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 2007 Sep;9(11):1260-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Vβ4 TCR Antibody (KT4) Related Classifications
HY-P990142 Related Classifications
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