Anti-MRSA agent 44 

Anti-MRSA agent 44 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. Anti-MRSA agent 44 exihibits antibiofilm activity against MRSA. Anti-MRSA agent 44 reduces bacterial counts and biofilm burdens, accelerates wound healing, lowers inflammatory cytokine levels in mouse models. Anti-MRSA agent 44 can be used for the research of MRSA skin wound infection and MRSA catheter-associated biofilm infection^[1].

Anti-MRSA agent 44 (compound 1i) (16-18 h) exhibits potent inhibition activity against various MRSA with MICs of 0.25-1 μg/mL^[1].
Anti-MRSA agent 44 (16-128 μg/mL, 24 h) shows no cytotoxicity in HK-2 and NIH3T3 cells^[1].
Anti-MRSA agent 44 (0.5-1 μg/mL) inhibits biofilm formation of MRSA 48, 52, and 936 in a dose-dependent manner^[1].
Anti-MRSA agent 44 (0.5-1 μg/mL) directly
interferes with the secretion of PIA by inhibiting the ica operon and suppresses the agr system, as evidenced by significant downregulation of RNAII, AIP-I, RNAIII, and the key virulence factor PSM α1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 44 (compound 1i) (0.25-1 mg/kg; local wound administration; at 1, 24, 48 h post-infection) exhibits dose-dependent antibacterial, anti-inflammatory, and wound-healing activity in a mouse MRSA wound infection model^[1].
Anti-MRSA agent 44 (compound 1i) (0.25-1 mg/kg; local catheter administration; at 1, 24, 48 h post-implantation) demonstrates potent dose-dependent activity against MRSA catheter-associated biofilms in mice, inhibiting biofilm formation and eradicating pre-formed biofilms, while reducing associated tissue inflammation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1854.56

C₇₈H₁₀₃Br₂N₁₇O₂₆

3123310-71-1

O=C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H]([C@H](OC([C@H](CC(C1=C(C=CC=C1)N)=O)NC([C@H]([C@@H](CC(O)=O)C)NC([C@H](NC(CNC([C@@H](NC2=O)CC(O)=O)=O)=O)CO)=O)=O)=O)C)C(NCC(N[C@H](C(N[C@H](C(N[C@@H]2C)=O)CC(O)=O)=O)CCCN)=O)=O)=O)CC(O)=O)=O)CC(N)=O)=O)CC3=C(NC4=C3C=CC=C4)C5=CC(Br)=CC(Br)=C5)CCCCCCCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yan T, et al. Postmodification of Daptomycin at Tryptophan Enables the Discovery of Aryl-Daptomycin Antibiofilm Activity against MRSA. J Med Chem. 2026 Jun 11;69(11):13504-13527.  [Content Brief]