Anti-Rat CD2 Antibody (OX-34)
Anti-Rat CD2 Antibody (OX-34) is mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD2. Anti-Rat CD2 Antibody (OX-34) can block CD2 and inhibit the mixed lymphocyte reaction. Anti-Rat CD2 Antibody (OX-34) can be used for the researches of cancer, inflammation and immunology, such as RNK-16 tumor and arthritis.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Rat
IC50 & Target
CD2
In Vitro
Anti-Rat CD2 Antibody (OX-34) (1 μg/mL) causes a prompt increase in [Ca2+]i in addition of goat F(ab')2 anti-mouse immunoglobulin in RNK-16 tumor cells[1].
Anti-Rat CD2 Antibody (OX-34) (1 μg per 106 cells, 3 mins) prevents the generation of InsP3 by RNK-16 tumor cells in response to YAC-1 tumor cells and blocks killing of YAC-1 tumor cells by RNK-16 tumor Cells[1].
Anti-Rat CD2 Antibody (OX-34) (1 μg/mL) (20 μg/mL, 90 h) inhibits the mixed lymphocyte reaction in rat spleen cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Rat CD2 Antibody (OX-34) (2 mg for the first time and 1 mg on the subsequent two days, i.p., two days before AA induction) prevents arthritis in adjuvant arthritis (AA) rat models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adjuvant arthritis (AA) rat models[2]
-
Dosage:2 mg for the first time and 1 mg on the subsequent two days
-
Administration:Intraperitoneally injection
-
Result:Reduced the arthritis scores.
Reduced hind paw thickness.
Reduced CD4+ T cells and activated T cells.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
Product Image
Application
in vivo CD2 blockade; in vitro CD2 blockade; Western blot
Chemical Information
-
Molecular Weight 150 kDa
-
SMILES
[Anti-Rat CD2 Antibody (OX-34)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Seaman WE, et al. Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4239-43. [Content Brief]
[2]. Hoffmann JC, et al. Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34. Ann Rheum Dis. 1997 Dec;56(12):716-22. [Content Brief]
[3]. Beyers AD, et al. Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol Rev. 1989 Oct;111:59-77. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Rat CD2 Antibody (OX-34) Related Classifications
HY-P990286 Related Classifications
Powered by Bioz