Antibacterial agent 350 hydrochloride
Based on 1 Customer Validation
Antibacterial agent 350 hydrochloride is a membrane stabilizer/disruptor with antibacterial activity. Antibacterial agent 350 hydrochloride reduces glucose-induced efflux efficiency and slightly impairs outer membrane stability. Antibacterial agent 350 hydrochloride significantly decreases the bacteriostatic MIC50 of Ceftazidime (HY-B0593) or Ciprofloxacin (HY-B0356), but increases the MIC50 of Amikacin (HY-B0509A). Antibacterial agent 350 hydrochloride can be used for the research of Pseudomonas aeruginosa infections.
For research use only. We do not sell to patients.
- Purity: 96.06%
- Formula: C25H51ClN4
- Molecular Weight:443.15
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Antibacterial agent 350 (compound 3) (15.6-125 μM; 60 min) hydrochloride causes slight outer membrane permeabilization in Pseudomonas aeruginosa PA01, but its primary activity is potent efflux inhibition, which is significantly greater than its permeabilization effect at all tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:CHO-K1 Chinese Hamster Ovary cells
-
Concentration:30-1200 μM
-
Incubation Time:24 h
-
Result:Had an IC50 of 320.5 μM for CHO-K1 cells, which is significantly higher than the IC50 of positive control doxorubicin (48.3 μM).
Chemical Information
-
Appearance Solid
-
Molecular Weight 443.15
-
Formula C25H51ClN4
-
Color Off-white to light yellow
-
SMILES
NCCCNCCCCNCCCNC/C=C(CC/C=C(CC/C=C(C)/C)\C)\C.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (262 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 350 hydrochloride Related Classifications
HY-185699B Related Classifications
Powered by Bioz