Antibacterial agent 350 TFA
Based on 1 Customer Validation
Antibacterial agent 350 TFA is a membrane stabilizer/disruptor with antibacterial activity. Antibacterial agent 350 TFA reduces glucose-induced efflux efficiency and slightly impairs outer membrane stability. Antibacterial agent 350 TFA significantly decreases the bacteriostatic MIC50 of Ceftazidime (HY-B0593) or Ciprofloxacin (HY-B0356), but increases the MIC50 of Amikacin (HY-B0509A). Antibacterial agent 350 TFA can be used for the research of Pseudomonas aeruginosa infections.
For research use only. We do not sell to patients.
- Purity : 96.06%
- Formula: C27H51F3N4O2
- Molecular Weight:520.71
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antibacterial agent 350 (compound 3) (15.6-125 μM; 60 min) TFA causes slight outer membrane permeabilization in Pseudomonas aeruginosa PA01, but its primary activity is potent efflux inhibition, which is significantly greater than its permeabilization effect at all tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO-K1 Chinese Hamster Ovary cells
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Concentration:30-1200 μM
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Incubation Time:24 h
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Result:Had an IC50 of 320.5 μM for CHO-K1 cells, which is significantly higher than the IC50 of positive control doxorubicin (48.3 μM).
Chemical Information
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Appearance Solid
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Molecular Weight 520.71
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Formula C27H51F3N4O2
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Color White to off-white
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SMILES
NCCCNCCCCNCCCNC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 350 TFA Related Classifications
HY-185699A Related Classifications
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