Anoctamin 1 Antibody (YA861)

製品番号: HY-P80963: データシート User Guide for Antibodies
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Anoctamin 1 Antibody (YA861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Anoctamin 1.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

Anoctamin 1 Antibody (YA861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Anoctamin 1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 114 kDa;

Observed band size: 114 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q5XXA6

Gene ID

55107 [NCBI]

Immunogen

Synthetic peptide corresponding to Human TMEM16A aa200-350/986.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Calcium-activated cH2O2ide channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated cH2O2ide conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated cH2O2ide channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity); Calcium-activated cH2O2ide channel (CaCC). Contributes to calcium-activated cH2O2ide secretion in human sweat gland epithelial cells. Shows increased basal cH2O2ide permeability and decreased Ca(2+)-induced cH2O2ide permeability; Calcium-activated cH2O2ide channel (CaCC). Shows increased sensitivity to intracellular Ca(2+)

Subcellular Localization：Apical cell membrane; Multi-pass membrane protein; Presynapse

Expression：
Tissue_specificity:Expressed in nasal epithelial cells (at protein level) (PubMed:32487539) . In the kidney, expressed in the collecting duct (at protein level) (PubMed:24913262) . Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles (PubMed:15215166, PubMed:16906560) . Expressed in eccrine sweat glands (PubMed:25220078)

Induction:By IL13 (PubMed:33026825) . By IL4, likely as a result of IL4-induced cell proliferation (PubMed:31732694) . By wounding in airway epithelial cells with levels decreasing significantly during the healing process (PubMed:31732694)

Isoforms & Post-Translational Modification：Q5XXA6 has 5 isomers: Q5XXA6-1: 114078 Da (predicted); Q5XXA6-2: 97736 Da (predicted); Q5XXA6-3: 74369 Da (predicted); Q5XXA6-4: 107201 Da (predicted); Q5XXA6-5: 120408 Da (predicted).

Subunit：Homodimer (PubMed:21056985, PubMed:28559167). Interacts with CFTR (PubMed:22178883, PubMed:28963502).

Database

Entrez Gene: 55107 Human

SwissProt: Q5XXA6 Human

OMIM: 620045 Human

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/tk-10-cell.html [Content Brief]