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  5. Anoctamin 1 Antibody (YA861)

Anoctamin 1 Antibody (YA861)

Art. -Nr.: HY-P80963
User Guide for Antibodies Technical Support

Anoctamin 1 Antibody (YA861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Anoctamin 1.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

  • Verweise

Beschreibung

Anoctamin 1 Antibody (YA861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Anoctamin 1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molekulargewicht
Predicted band size: 114 kDa;
Observed band size: 114 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Human TMEM16A aa200-350/986.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Calcium-activated cH2O2ide channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated cH2O2ide conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated cH2O2ide channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity); Calcium-activated cH2O2ide channel (CaCC). Contributes to calcium-activated cH2O2ide secretion in human sweat gland epithelial cells. Shows increased basal cH2O2ide permeability and decreased Ca(2+)-induced cH2O2ide permeability; Calcium-activated cH2O2ide channel (CaCC). Shows increased sensitivity to intracellular Ca(2+)
Subcellular Localization：Apical cell membrane; Multi-pass membrane protein; Presynapse
Expression：
Tissue_specificity:Expressed in nasal epithelial cells (at protein level) (PubMed:32487539) . In the kidney, expressed in the collecting duct (at protein level) (PubMed:24913262) . Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles (PubMed:15215166, PubMed:16906560) . Expressed in eccrine sweat glands (PubMed:25220078)

Induction:By IL13 (PubMed:33026825) . By IL4, likely as a result of IL4-induced cell proliferation (PubMed:31732694) . By wounding in airway epithelial cells with levels decreasing significantly during the healing process (PubMed:31732694)
Isoforms & Post-Translational Modification：Q5XXA6 has 5 isomers: Q5XXA6-1: 114078 Da (predicted); Q5XXA6-2: 97736 Da (predicted); Q5XXA6-3: 74369 Da (predicted); Q5XXA6-4: 107201 Da (predicted); Q5XXA6-5: 120408 Da (predicted).
Subunit：Homodimer (PubMed:21056985, PubMed:28559167). Interacts with CFTR (PubMed:22178883, PubMed:28963502).
Database

Entrez Gene: 55107 Human

SwissProt: Q5XXA6 Human

OMIM: 620045 Human

Dokumentation
User Guide for Antibodies (1077 KB)
Verweise

Anoctamin 1 Antibody (YA861) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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