ANO1 - anoctamin 1 Gene

Also Known as DOG1; INDMS; TAOS2; ORAOV2; TMEM16A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55107

About ANO1

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:69,965,997-70,189,530 (from NCBI)

This gene has 10 transcripts (splice variants), 298 orthologues, 10 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 23.9), salivary gland (RPKM 22.1) and 16 other tissues.

Summary

Enables calcium activated cation channel activity; intracellular calcium activated Chloride Channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANO1 Products (7)

mRNA	Protein	Name
NM_001378092.1	NP_001365021.1	anoctamin-1 isoform b
NM_001378093.1	NP_001365022.1	anoctamin-1 isoform c
NM_001378094.2	NP_001365023.1	anoctamin-1 isoform c
NM_001378095.2	NP_001365024.1	anoctamin-1 isoform d
NM_001378096.2	NP_001365025.1	anoctamin-1 isoform e
NM_001378097.2	NP_001365026.1	anoctamin-1 isoform f
NM_018043.7	NP_060513.5	anoctamin-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-activated cation channel activity	IDA IDA: Inferred from direct assay	22946059	GOA
enables chloride channel activity	IDA IDA: Inferred from direct assay	32487539	GOA
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	24885604	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	28559167	GOA
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	21984732	GOA
enables intracellularly calcium-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	22178883	GOA
enables iodide transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	25201006	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22178883	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	32487539	GOA
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	22946059	GOA
involved in chloride transport	IMP IMP: Inferred from mutant phenotype	28963502	GOA
involved in iodide transport	IMP IMP: Inferred from mutant phenotype	25201006	GOA
involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	33026825	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IGI IGI: Inferred from genetic interaction	24885604	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24885604	GOA
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	28963502	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	25201006	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21984732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANO1 Protein Structure

Anoctamin

0
200
400
600
800
986 a.a.

Protein Preferred Names	Protein Names
anoctamin-1	Ca2+-activated Cl- channel

Recombinant ANO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700616	ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc)	Q5XXA6-1 (S806-A892)	≥ 95%, as determined by reducing SDS-PAGE.

ANO1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80963	Anoctamin 1 Antibody (YA861)	IHC-P, FC	Human

Related Diseases

Diseases	Alias
Intestinal Dysmotility Syndrome	IDMTS
Gastric Leiomyoma	Leiomyoma Of The Stomach
Chondroblastoma	Chondroblastoma Of Bone
Colon Leiomyosarcoma	Colonic Leiomyosarcoma
Tracheomalacia	Congenital Tracheomalacia Congenital Major Airway Collapse Tracheomalacia, Congenital Type 1 Tracheomalacia
Small Intestine Leiomyosarcoma	Leiomyosarcoma Of The Small Bowel Smooth Muscle Connective Tissue Tumor Leiomyosarcoma Of Small Intestine
Small Intestine Leiomyoma	Leiomyoma, Small Bowel Leiomyoma Of Small Intestine
Liver Leiomyoma	Leiomyoma Of The Liver
Neurofibroma Of The Esophagus
Gastric Leiomyosarcoma	Leiomyosarcoma Of Stomach
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Deep Leiomyoma
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Gastric Liposarcoma	Liposarcoma Of The Stomach
Liver Leiomyosarcoma	Leiomyosarcoma Of The Liver
Colon Leiomyoma	Colonic Leiomyoma
Tracheal Disease	Tracheal Diseases Tracheal Anomaly Tracheal Disorders
Jejunal Neoplasm	Jejunal Tumor Neoplasm Of Jejunum Tumor Of Jejunum
Small Intestinal Sarcoma	Sarcoma Of The Small Intestine
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Kidney Leiomyosarcoma	Leiomyosarcoma Of Kidney
Bilateral Hypoactive Labyrinth	Hypoactive Bilateral Labyrinthine Dysfunction Hypoactive Labyrinth, Bilateral
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Small Intestine Benign Neoplasm	Neoplasm Of Small Intestine Small Intestinal Neoplasm Neoplasm Of The Small Intestine Small Bowel Cancer Small Intestine Cancer Malignant Neoplasm Of Small Intestine, Unspecified Malignant Tumour Of Small Bowel Malignant Tumour Of Small Intestine Primary Malignant Neoplasm Of Meckel Diverticulum
Retroperitoneal Leiomyosarcoma
Sarcomatous Intrahepatic Cholangiocarcinoma	Sarcomatoid Intrahepatic Cholangiocarcinoma
Esophageal Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma, Esophagus
Constipation
Inner Ear Disease	Labyrinthine Dysfunction Diseases Of Inner Ear Labyrinthine Disease Abnormality Of The Inner Ear Labyrinth Diseases Labyrinthine Disorder Nonfunctioning Labyrinth Labyrinthine Loss Of Function Labyrinthine Syndrome Labyrinthine Disorder Nos
Gastric Hemangioma	Hemangioma Of Stomach
Mammary Analogue Secretory Carcinoma
Acinar Cell Carcinoma	Acinic Cell Carcinoma Acinic Cell Tumor Carcinoma Acinar Cell Carcinoma, Acinar Cell Acinar Cell Tumor
Gallbladder Leiomyosarcoma	Leiomyosarcoma Of The Gallbladder
Lipoma Of Spermatic Cord	Spermatic Cord Lipoma
Paratesticular Lipoma
Active Peptic Ulcer Disease	Gi Bleeding Active Peptic Ulcer Gastrointestinal Hemorrhage
Angiomyoma	Vascular Leiomyoma
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Cellular Schwannoma	Cellular Neurinoma
Scott Syndrome	SCTS Bdplt7 Prothrombin Consumption Deficiency Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X Bleeding Disorder, Platelet-Type, 7 Prothrombin Conversion Defect, Familial Prothrombin Consumption Inhibitor, Familial Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X Familial Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Platelet-Type Bleeding Disorder 7 Platelet Factor X Receptor Deficiency Bleeding Disorder Platelet-Type 7 Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Familial
Perivascular Tumor	Malignant Perivascular Cancer
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Epithelial-Myoepithelial Carcinoma	Clear Cell Adenoma Adenomyo-Epithelioma Clear Cell Carcinoma Emc Epithelial Myoepithelial Carcinoma Glycogen-Rich Adenocarcinoma Glycogen-Rich Adenoma Monomorphic Clear Cell Tumor Tubular Solid Adenoma Adenocarcinoma, Clear Cell
Chondroma	Central Chondroma Enchondroma
Gnathodiaphyseal Dysplasia	GDD Osteogenesis Imperfecta With Unusual Skeletal Lesions Gnathodiaphyseal Sclerosis Osteogenesis Imperfecta, Levin Type Levin Syndrome 2 Dysplasia, Gnathodiaphyseal
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon
Retroperitoneal Sarcoma
Benign Peritoneal Mesothelioma	Mesothelioma Of Peritoneum Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Miyoshi Muscular Dystrophy 3	MMD3 Miyoshi Myopathy 3 Distal Anoctaminopathy Miyoshi Muscular Dystrophy Type 3 Dystrophy, Muscular, Miyoshi, Type 3
Conventional Leiomyosarcoma
Malignant Granular Cell Myoblastoma	Malignant Granular Cell Tumor Granular Cell Tumor, Malignant Malignant Granular Cell Neoplasm
Epithelioid Leiomyosarcoma	Leiomyosarcoma Epithelioid Leiomyosarcoma, Epithelioid
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Plexiform Schwannoma	Plexiform Neurilemmoma Plexiform Neurinoma
Glomus Tumor	Glomus Neoplasm Glomus Tumour
Breast Secretory Carcinoma	Secretory Breast Carcinoma Juvenile Breast Carcinoma Juvenile Carcinoma Of The Breast Juvenile Secretory Carcinoma Of Breast Juvenile Breast Cancer Sbc Secretory Carcinoma Of The Breast
Perivascular Epithelioid Cell Tumor	Pecoma Perivascular Epithelioid Cell Neoplasms Neoplasm With Perivascular Epithelioid Cell Differentiation
Smooth Muscle Tumor
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Functional Gastric Disease
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Benign Ileal Neoplasm	Ileal Tumor Ileal Neoplasms Ileal Neoplasm
Secretory Diarrhea
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Intravascular Fasciitis	Intravascular Pseudosarcomatous Fasciitis
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Endobronchial Leiomyoma
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Extraosseous Osteosarcoma	Extraskeletal Osteosarcoma Extraskeletal Osteogenic Sarcoma
Pulmonary Artery Leiomyosarcoma	Leiomyosarcoma Of The Pulmonary Artery
Neuroma
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Prostate Stromal Sarcoma	Stromal Sarcoma Of The Prostate
Lipoma Of Colon	Colonic Lipoma Colon Lipoma
Large Intestine Lipoma	Lipoma Of Large Intestine Colorectal Lipoma
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119981	Ani9	Inhibitor	99.12%	Unkown
HY-100612	T16Ainh-A01	Inhibitor	99.04%	Unkown
HY-146320	ANO1-IN-1	Inhibitor	99.57%	Unkown
HY-105917	Emidurdar	Inhibitor	99.41%	Yes
HY-146334	DFBTA	Inhibitor	99.25%	Unkown
HY-153508	ANO1-IN-4	Inhibitor	99.58%	Unkown
HY-118170	T16A(inh)-C01	Inhibitor	90%	Unkown
HY-N4253	Kudinoside D		99.80%	Unkown
HY-N5101	Kobusin		99.93%	Unkown
HY-146321	ANO1-IN-2	Inhibitor	/	Unkown
HY-147874	ANO1-IN-3		/	Unkown
HY-175669	ANO1-IN-5	Inhibitor	/	Unkown
HY-RS00740	ANO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00750	ANOS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-114457	Phosphatidylinositol 4,5-bisphosphate	Substrate	/	Unkown
HY-RS17326	Ano1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23781	Ano1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990337	Anti-ANO1/TMEM16A Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANO1	VGNC	VGNC:69668
Felis catus	ANO1	VGNC	VGNC:59827
Mus musculus	ANO1	MGD	MGI:2142149
Rattus norvegicus	ANO1	RGD	RGD:1310786
Bos taurus	ANO1	VGNC	VGNC:50077
Canis familiaris	ANO1	VGNC	VGNC:37923
Others	ANO1	NCBI