BDNF Antibody(YA9955)
(Synonyms: BDNF; MGC34632; Abrineurin; ANON2; Brain Derived Neurotrophic Factor; Neurotrophin; BULN2)
Based on 1 Customer Validation
BDNF Antibody(YA9955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BDNF.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in Rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-1:20000 | 1:50-1:500 | 1:50-1:200 |
Product Details
BDNF Antibody(YA9955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BDNF.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 15-45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 28 kDa
Entrez Gene: 627 Human ; 12064 Mouse ; 24225 Rat
SwissProt: P23560 Human ; P21237 Mouse ; P23363 Rat
OMIM: 113505 Human
Synthetic peptide corresponding to Human BDNF aa150-200.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in Rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BDNF is important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability[1].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Detected in blood plasma and in saliva (at protein level). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. -
Isoforms & Post-Translational Modification
BDNF has 5 isoforms, P23560-1: amino acid length is 247, molecular weight is 27818 Da (predicted); P23560-2: amino acid length is 255, molecular weight is 28872 Da (predicted); P23560-3: amino acid length is 262, molecular weight is 29817 Da (predicted); P23560-4: amino acid length is 329, molecular weight is 37120 Da (predicted); P23560-5: amino acid length is 276, molecular weight is 31116 Da (predicted).N-glycosylated and glycosulfated, contrary to mature BDNF
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Subunit
Monomers and homodimers.
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SwissProt ID
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Synonyms
BDNF; MGC34632; Abrineurin; ANON2; Brain Derived Neurotrophic Factor; Neurotrophin; BULN2
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Research Field
Neuroscience
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