BDNF - brain derived neurotrophic factor Gene
Also Known as ANON2; BULN2
Species: Homo sapiens
About BDNF
This gene has 17 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 3.0), lung (RPKM 1.2) and 11 other tissues.
Summary
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
BDNF Products (17)
| mRNA | Protein | Name |
|---|---|---|
| NM_001143805.1 | NP_001137277.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143806.1 | NP_001137278.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143807.2 | NP_001137279.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143808.2 | NP_001137280.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143809.2 | NP_001137281.1 | brain-derived neurotrophic factor isoform d |
| NM_001143810.2 | NP_001137282.1 | brain-derived neurotrophic factor isoform e |
| NM_001143811.2 | NP_001137283.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143812.2 | NP_001137284.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143813.2 | NP_001137285.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143814.2 | NP_001137286.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001143816.2 | NP_001137288.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_001709.5 | NP_001700.2 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_170731.5 | NP_733927.1 | brain-derived neurotrophic factor isoform b precursor |
| NM_170732.4 | NP_733928.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_170733.4 | NP_733929.1 | brain-derived neurotrophic factor isoform a preproprotein |
| NM_170734.4 | NP_733930.1 | brain-derived neurotrophic factor isoform c |
| NM_170735.6 | NP_733931.1 | brain-derived neurotrophic factor isoform a preproprotein |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7703225 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in collateral sprouting |
IDA
IDA: Inferred from direct assay
|
19036963 | GOA |
| involved in positive regulation of collateral sprouting |
IDA
IDA: Inferred from direct assay
|
19036963 | GOA |
| involved in positive regulation of receptor binding |
IDA
IDA: Inferred from direct assay
|
12130635 | GOA |
| involved in positive regulation of synapse assembly |
IDA
IDA: Inferred from direct assay
|
19036963 | GOA |
| involved in synapse assembly |
IDA
IDA: Inferred from direct assay
|
19036963 | GOA |
BDNF Protein Structure
NGF: Nerve growth factor family (132 - 247)
- 0
- 100
- 200
- 247 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
brain-derived neurotrophic factor |
|
BDNF Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
BDNF | P23560 | NTF4 | Homo sapiens | P34130 | 10631974 | |
|
Intra
|
BDNF | P23560 | NTF4 | Homo sapiens | P34130 | 29997244 | |
|
Intra
|
BDNF | P23560 | NTF4 | Homo sapiens | P34130 | 29997244 |
Recombinant BDNF Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P7116 | BDNF Protein, Human/Mouse/Rat (CHO) | P23560-1 (H129-R247)/P21237-1 (H131-R249)/P23363 (H131-R249) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7116A | BDNF Protein, Human/Mouse/Rat | P23560-1 (H129-R247)/P21237-1 (H131-R249)/P23363 (H131-R249) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72489 | BDNF Protein, Human (R125A, R127A, R128A) | P23560-1 (A19-R247, R125A, R127A, R128A) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700158AF | Animal-Free BDNF Protein, Human/Mouse/Rat (His) | P23560-1 (H129-R247)/P21237-1 (H131-R249)/P23363 (H131-R249) | ≥ 95%, as determined by reducing SDS-PAGE. |
BDNF Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P80567 | BDNF Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P80567A | BDNF Antibody(YA9955) | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P84197 | BDNF Antibody (YA3894) | WB, ICC/IF, ELISA | Human |
| HY-P84197A | BDNF Antibody (YA3894)(PBS only) | WB, ICC/IF, ELISA | Human |
| HY-P86086 | BDNF Antibody (YA5778) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spinal Cord Injury |
|
|
| Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome |
|
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| Mood Disorder |
|
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| Congenital Central Hypoventilation Syndrome |
|
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| Major Depressive Disorder |
|
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| Rett Syndrome |
|
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| Eating Disorder |
|
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| Substance Abuse |
|
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| Anxiety |
|
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| Borderline Personality Disorder |
|
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| Bulimia Nervosa |
|
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| Fragile X Syndrome |
|
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| Post-Traumatic Stress Disorder |
|
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| Cannabis Abuse |
|
|
| Status Epilepticus |
|
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| Dementia |
|
|
| Obsessive-Compulsive Disorder |
|
|
| Trichotillomania |
|
|
| Trigeminal Neuralgia |
|
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| Bipolar Disorder |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Back Pain |
|
|
| Anorexia Nervosa |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Central Nervous System Disease |
|
|
| Schizoaffective Disorder |
|
|
| Temporal Lobe Epilepsy |
|
|
| Huntington Disease |
|
|
| Premature Ejaculation |
|
|
| Fibromyalgia |
|
|
| Aphasia |
|
|
| Blepharospasm |
|
|
| Personality Disorder |
|
|
| Motor Neuron Disease |
|
|
| Mental Depression |
|
|
| Heroin Dependence |
|
|
| Diabetic Encephalopathy |
|
|
| Polyradiculoneuropathy |
|
|
| Bruxism |
|
|
| Hereditary Sensory Neuropathy |
|
|
| Melancholia |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Neuropathy, Hereditary Sensory And Autonomic, Type Iii |
|
|
| Neuritis |
|
|
| Irritable Bowel Syndrome |
|
|
| Asperger Syndrome |
|
|
| Toxic Encephalopathy |
|
|
| Sleep Apnea |
|
|
| Meningoencephalitis |
|
|
| Panic Disorder |
|
|
| Sudden Infant Death Syndrome |
|
|
| Retrograde Amnesia |
|
|
| Optic Neuritis |
|
|
| Psychotic Disorder |
|
|
| Autism Spectrum Disorder |
|
|
| Autism |
|
|
| Endogenous Depression |
|
|
| Speech And Communication Disorders |
|
|
| Aniridia 1 |
|
|
| Acute Stress Disorder |
|
|
| Cystitis |
|
|
| Ischemia |
|
|
| Neurotic Disorder |
|
|
| Fetal Alcohol Spectrum Disorder |
|
|
| Multiple Sclerosis |
|
|
| Disease Of Mental Health |
|
|
| Cerebral Artery Occlusion |
|
|
| Amnestic Disorder |
|
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| Chronic Pain |
|
|
| Adrenal Gland Pheochromocytoma |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Schizophrenia |
|
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| Anterograde Amnesia |
|
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| Atypical Depressive Disorder |
|
|
| Insensitivity To Pain, Congenital, With Anhidrosis |
|
|
| Dysthymic Disorder |
|
|
| Constipation |
|
|
| Postpartum Depression |
|
|
| Angelman Syndrome |
|
|
| Essential Tremor |
|
|
| Mild Cognitive Impairment |
|
|
| Phobic Disorder |
|
|
| Bipolar I Disorder |
|
|
| Dissociative Disorder |
|
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| Dyslexia |
|
|
| Specific Developmental Disorder |
|
|
| Somatoform Disorder |
|
|
| Cerebral Palsy |
|
|
| Alcohol Dependence |
|
|
| Acrofacial Dysostosis, Catania Type |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Narcolepsy |
|
|
| Hypochondriasis |
|
|
| Frontotemporal Dementia |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Prader-Willi Syndrome |
|
|
| Hyperglycemia |
|
|
| Adjustment Disorder |
|
|
| Hypoglycemia |
|
|
| Myofascial Pain Syndrome |
|
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| Glucose Intolerance |
|
|
| Fetal Alcohol Syndrome |
|
|
| Epilepsy |
|
|
| Gene Duplication Disease |
|
|
| Occlusion Precerebral Artery |
|
|
| Carotid Artery Occlusion |
|
|
| Sensory Peripheral Neuropathy |
|
|
| Sensorineural Hearing Loss |
|
|
| Retinal Ischemia |
|
|
| Leptin Deficiency Or Dysfunction |
|
|
| Paranoid Schizophrenia |
|
|
| Generalized Anxiety Disorder |
|
|
| Hydrocephalus |
|
|
| Social Phobia |
|
|
| Schizophreniform Disorder |
|
|
| Nerve Fibre Bundle Defect |
|
|
| Phobia, Specific |
|
|
| Opiate Dependence |
|
|
| Diabetic Polyneuropathy |
|
|
| Retinal Degeneration |
|
|
| Headache |
|
|
| Pervasive Developmental Disorder |
|
|
| Separation Anxiety Disorder |
|
|
| Substance Dependence |
|
|
| Paine Syndrome |
|
|
| Interstitial Cystitis |
|
|
| Sleep Disorder |
|
|
| Down Syndrome |
|
|
| Dystonia |
|
|
| Trigeminal Nerve Disease |
|
|
| Alcohol Use Disorder |
|
|
| Vascular Dementia |
|
|
| Asphyxia Neonatorum |
|
|
| Conversion Disorder |
|
|
| Complex Regional Pain Syndrome |
|
|
| Amblyopia |
|
|
| Wernicke-Korsakoff Syndrome |
|
|
| Diarrhea |
|
|
| Nutritional Deficiency Disease |
|
|
| Impulse Control Disorder |
|
|
| Substance-Induced Psychosis |
|
|
| Cocaine Abuse |
|
|
| Learning Disability |
|
|
| Cyclothymic Disorder |
|
|
| Alexithymia |
|
|
| Deafness, Autosomal Dominant 33 |
|
|
| Encephalomalacia |
|
|
| Chromosomal Duplication Syndrome |
|
|
| Agoraphobia |
|
|
| Neuroblastoma |
|
|
| Agnosia |
|
|
| Ocular Dominance |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Subjective Cognitive Decline |
|
|
| Drug Dependence |
|
|
| Thiamine Deficiency Disease |
|
|
| Childhood Disintegrative Disease |
|
|
| Withdrawal Disorder |
|
|
| Pain Agnosia |
|
|
| Diabetic Neuropathy |
|
|
| Lumbosacral Plexus Lesion |
|
|
| Focal Epilepsy |
|
|
| Glaucoma, Normal Tension |
|
|
| Neuropathy, Hereditary Sensory And Autonomic, Type V |
|
|
| Periventricular Leukomalacia |
|
|
| Syringomyelia |
|
|
| Allergic Disease |
|
|
| Myopia |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Cranial Nerve Disease |
|
|
| Autonomic Nervous System Disease |
|
|
| Oppositional Defiant Disorder |
|
|
| Choreatic Disease |
|
|
| Neurogenic Bladder |
|
|
| Cerebrovascular Disease |
|
|
| Dementia, Lewy Body |
|
|
| Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type |
|
|
| Apnea, Obstructive Sleep |
|
|
| Diabetes Mellitus |
|
|
| Cardiovascular System Disease |
|
|
| Neonatal Hypoxic And Ischemic Brain Injury |
|
|
| Demyelinating Disease |
|
|
| Chromosomal Disease |
|
|
| Breast Cancer |
|
|
| Tobacco Addiction |
|
|
| Chronic Fatigue Syndrome |
|
|
| Dermatitis, Atopic |
|
|
| Movement Disease |
|
|
| Intraocular Pressure Quantitative Trait Locus |
|
|
| Exudative Vitreoretinopathy 1 |
|
|
| Osteoporosis |
|
|
| Peripheral Nervous System Disease |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Tetralogy Of Fallot |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Optic Nerve Disease |
|
|
| Syndromic X-Linked Intellectual Disability |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Medulloblastoma |
|
|
| Gilles De La Tourette Syndrome |
|
|
| Glaucoma, Primary Open Angle |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Stroke, Ischemic |
|
|
| Skin Disease |
|
|
| Syndromic Intellectual Disability |
|
|
| Pick Disease Of Brain |
|
|
| Hypertension, Essential |
|
|
| Nervous System Disease |
|
|
| Autosomal Dominant Cerebellar Ataxia |
|
|
| Myeloma, Multiple |
|
|
| Amelogenesis Imperfecta |
|
|
| Eye Disease |
|
|
| Neuromuscular Disease |
|
|
| Congenital Nervous System Abnormality |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Retinitis Pigmentosa |
|
|
| Fundus Dystrophy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | BDNF | VGNC | VGNC:99552 |
| Bos taurus | BDNF | VGNC | VGNC:26461 |
| Mus musculus | BDNF | MGD | MGI:88145 |
| Rattus norvegicus | BDNF | RGD | RGD:2202 |
| Others | BDNF | NCBI |