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BDNF Antibody (YA5778)

(Synonyms: Abrineurin antibody; ANON2 antibody; BDNF antibody; BDNF_HUMAN antibody; Brain Derived Neurotrophic Factor antibody; Brain-derived neurotrophic factor antibody; BULN2 antibody; MGC34632 antibody; Neurotrophin antibody)
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BDNF Antibody (YA5778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BDNF.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, IP, ELISA

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • BDNF Antibody (YA5778) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:2000-1:10000 1:2000-1:10000 1:200-1:1000 1:5000-1:20000 1:50-1:200

Product Details

Description

BDNF Antibody (YA5778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BDNF.

  • Host Rabbit
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 15-45 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 15 kDa
Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    BDNF is important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse[1][2][3].

  • Subcellular Localization

    Secreted; Secreted

  • Expression


    Tissue_specificity:Protein levels were detected in both plasma and saliva (PubMed: 11152678, PubMed: 19467646) . High expression was observed in the hippocampus, amygdala, cerebral cortex, and cerebellum of brain tissue. It was also expressed in the heart, lungs, skeletal muscle, testes, prostate, and placenta.

  • Isoforms & Post-Translational Modification

    P23560 has 5 isomers: P23560-1: 27818 Da (predicted); P23560-2: 28872 Da (predicted); P23560-3: 29817 Da (predicted); P23560-4: 37120 Da (predicted); P23560-5: 31116 Da (predicted).
    N-glycosylated and glycosulfated, contrary to mature BDNF;Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646)

  • Subunit

    Monomers and homodimers. Binds to NTRK2/TRKB (PubMed:11152678, PubMed:8527932). Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (PubMed:10631974, PubMed:7703225). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2 (PubMed:24908487)

  • SwissProt ID

    P23560

  • Gene ID
    627 [NCBI]
  • Synonyms

    Abrineurin antibody; ANON2 antibody; BDNF antibody; BDNF_HUMAN antibody; Brain Derived Neurotrophic Factor antibody; Brain-derived neurotrophic factor antibody; BULN2 antibody; MGC34632 antibody; Neurotrophin antibody

BDNF Antibody (YA5778) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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