CABP1 Antibody (YA6490)
(Synonyms: CABP 1 antibody; CaBP1 antibody; CABP1_HUMAN antibody; Calbrain antibody; Calcium binding protein 1 antibody; Calcium binding protein 5 antibody; Calcium-binding protein 1 antibody; Caldendrin antibody; HCALB BR antibody; HCALB_BR antibody; )CABP1 Antibody (YA6490) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CABP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:500-1:1000 |
Product Details
CABP1 Antibody (YA6490) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CABP1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
Synthetic peptide within Human CABP aa 150-250.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CABP1 modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina[1][2][3][4][5].
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Subcellular Localization
Cytoplasm, cytoskeleton,Cytoplasm, perinuclear region,Cell membrane,Golgi apparatus,Postsynaptic density,Cytoplasm, cytoskeleton,Cytoplasm, cell cortex,Cell membrane
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Expression
Tissue_Specificity: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum -
Isoforms & Post-Translational Modification
Q9NZU7 has four isomers: Q9NZU7-4: 39838 Da (predicted); Q9NZU7-1: 25979 Da (predicted); Q9NZU7-2: 19430 Da (predicted); Q9NZU7-3: 8139 Da (predicted).
Phosphorylated -
Subunit
Homodimer; when bound to calcium or magnesium
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SwissProt ID
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Synonyms
CABP 1 antibody; CaBP1 antibody; CABP1_HUMAN antibody; Calbrain antibody; Calcium binding protein 1 antibody; Calcium binding protein 5 antibody; Calcium-binding protein 1 antibody; Caldendrin antibody; HCALB BR antibody; HCALB_BR antibody;
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