2. Gene
  3. CABP1 - calcium binding protein 1 Gene

CABP1 - calcium binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CALBRAIN; HCALB_BR

Gene ID: 9478 | Gene type: protein coding

About CABP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,640,626-120,680,866 (from NCBI)

This gene has 5 transcripts (splice variants), 292 orthologues and 20 paralogues. Biased expression in brain (RPKM 5.5), fat (RPKM 2.2) and 5 other tissues.

Summary

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to Calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type Calcium Channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

CABP1 Products(3)

mRNA Protein Name
NM_001033677.2 NP_001028849.1 calcium-binding protein 1 isoform 3
NM_004276.5 NP_004267.2 calcium-binding protein 1 isoform 2
NM_031205.4 NP_112482.1 calcium-binding protein 1 isoform 1

CABP1 Protein Structure

EF-hand_1

EF-hand_1: EF hand (229 - 257)

EF-hand_7

EF-hand_7: EF-hand domain pair (307 - 368)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

calcium-binding protein 1

calcium binding protein 5

Related Diseases

Diseases Alias
Spinal Cord Lymphoma

Lymphoma Of The Spinal Cord

Spinal Cord Cancer

Spine Lymphoma

Spinal Cord--Cancer
Drug Psychosis

Drug-Induced Psychosis

Drug-Induced Psychotic Disorder

Psychoses, Substance-Induced

Psychoses, Drug
Drug-Induced Mental Disorder
Tinea Nigra

Microsporosis Nigra

Infection By Cladosporium Werneckii

Keratomycosis Nigricans

Tinea Palmaris Nigra

Keratomycosis Nigricans Palmaris
Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy

PACD

Chromosome 12q21.33 Deletion Syndrome

Posterior Amorphous Stromal Dystrophy
Substance-Induced Psychosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14737A Ceftaroline fosamil hydrate Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0987 Stains-All 99.91% Unkown
HY-RS01783 CABP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CABP1 VGNC VGNC:60285
Bos taurus CABP1 VGNC VGNC:53893
Rattus norvegicus CABP1 RGD RGD:620385
Macaca mulatta CABP1 VGNC VGNC:70495
Mus musculus CABP1 MGD MGI:1352750
Canis familiaris CABP1 VGNC VGNC:106592