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CD14 Antibody (YA3709)

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CD14 Antibody (YA3709) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD14.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, FC, ELISA

  • Reactivity :

    Human, Mouse, Rat, Rabbit

  • Formulation:

    Supplied in PBS with 0.05% sodium azide

  • Conjugation:
    Non-conjugated
  • CD14 Antibody (YA3709) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

CD14 Antibody (YA3709) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD14.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat, Rabbit
  • Observed Molecular Weight
    Observed band size: 55 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 40 kDa
Immunogen

Purified recombinant fragment of human CD14 (AA: 20-214) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3718812

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% sodium azide

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD14 is an important innate immune pattern recognition receptor, primarily serving as a component of the lipopolysaccharide (LPS) receptor complex. It plays a crucial role in recognizing Gram-negative bacteria and their products, and in activating inflammatory responses. CD14 itself lacks a transmembrane signal transduction structure; therefore, it typically functions as a co-receptor in synergy with TLR4 and MD-2.

  • Subcellular Localization

    Cell membrane; Lipid-anchor, GPI-anchor; Secreted; Membrane raft; Golgi apparatus

  • Expression


    Tissue_specificity:Protein levels were detected on macrophages (PubMed: 1698311) . It is strongly expressed on the surface of monocytes and weakly expressed on the surface of granulocytes; it is also expressed in macrophages of most tissues.

    Induction:The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced

  • Subunit

    Interacts with LPS-bound LPB. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4.

  • SwissProt ID

    P08571

  • Gene ID
    929 [NCBI]

CD14 Antibody (YA3709) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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