CD14 - CD14 molecule Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 929

About CD14

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,631,732-140,633,701 (from NCBI)

This gene has 4 transcripts (splice variants) and 118 orthologues. Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues.

Summary

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with Other proteins to mediate the innate immune response to Bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]

CD14 Products (4)

mRNA	Protein	Name
NM_000591.4	NP_000582.1	monocyte differentiation antigen CD14 precursor
NM_001040021.3	NP_001035110.1	monocyte differentiation antigen CD14 precursor
NM_001174104.2	NP_001167575.1	monocyte differentiation antigen CD14 precursor
NM_001174105.2	NP_001167576.1	monocyte differentiation antigen CD14 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables lipopolysaccharide immune receptor activity	IDA IDA: Inferred from direct assay	15294986	GOA
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16880211	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	15294986	GOA
involved in cellular response to diacyl bacterial lipopeptide	IDA IDA: Inferred from direct assay	16880211	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12594207	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	8612135	GOA
acts upstream of or within cellular response to lipoteichoic acid	IDA IDA: Inferred from direct assay	12594207	GOA
involved in cellular response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	15039339	GOA
involved in cellular response to triacyl bacterial lipopeptide	IDA IDA: Inferred from direct assay	16880211	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	15039339	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12594207	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	8612135	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	27986454	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16880211	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	3385210	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	7537731	GOA
part of lipopolysaccharide receptor complex	IDA IDA: Inferred from direct assay	11274165	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	16880211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD14 Protein Structure

LRR_6

LRR_1

0
100
200
300
375 a.a.

Protein Preferred Names	Protein Names
monocyte differentiation antigen CD14	myeloid cell-specific leucine-rich glycoprotein

CD14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD14	P08571	FSTL1	Homo sapiens	Q12841	SPR	20860622
Intra	CD14	P08571	FSTL1	Homo sapiens	Q12841	FACS	22265692

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7786	CD14 Protein, Human (HEK293, His)	P08571 (T20-C352)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74333	CD14 Protein, Human (HEK293, Fc)	P08571 (T20-C352)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78918	CD14 Protein, Human (Biotinylated, HEK293, His-Avi)	P08571 (T20-M344)	≥ 95%, as determined by reducing SDS-PAGE.

CD14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81096	CD14 Antibody	WB, IHC-P, ICC/IF	Human
HY-P84012	CD14 Antibody (YA3709)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P84012A	CD14 Antibody (YA3709)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
HY-P86452	CD14 Antibody (YA6144)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
HY-P86473	CD14 Antibody (YA6165)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mycobacterium Chelonae
Croup	Acute Obstructive Laryngitis Laryngotracheobronchitis Acute Laryngotracheobronchitis Croup Syndrome Acute Laryngitis With Obstruction Obstructive Laryngitis Obstructive Laryngitis Nos Obstructive Laryngotracheitis Nos
Monocytic Leukemia	Monocytic Leukaemia Schilling'S Leukaemia Schilling'S Leukemia M5b Acute Differentiated Monocytic Leukemia
Paroxysmal Nocturnal Hemoglobinuria	Marchiafava-Micheli Disease Pnh Hemoglobinuria, Paroxysmal Marchiafava-Micheli Syndrome Paroxysmal Hemoglobinuria Nocturnal Nocturnal Haemoglobinuria Nocturnal Paroxysmal Haematuria Nocturnal Paroxysmal Haemoglobinaemia
Mycobacterium Kansasii	Infection Due To Mycobacterium Kansasii
Leukemia, Acute Monocytic	Acute Monocytic Leukemia Acute Monoblastic Leukemia And Acute Monocytic Leukemia Acute Monocytic Leukaemia Acute Monocytic Leukaemia Without Mention Of Remission Acute Monocytic Leukemia Without Mention Of Remission Acute Monocytic Leukemia, Fab M5 Acute Monocytic Leukemia, Morphology Leukemia, Monocytic, Acute M5b Acute Differentiated Monocytic Leukemia
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Viral Meningitis	Meningitis Viral Meningitis, Viral Viral Meningitis Nec
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Arteriosclerosis	Arteriosclerotic Vascular Disease
Enterocolitis
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Ige Responsiveness, Atopic	ATOPY Atopy, Susceptibility To Ige, Elevated Level Of IGER Immunoglobulin E, Basic Level Of, In Serum Ige, Level Of Igel Ige Response Underlying Allergic Asthma And Rhinitis Atopic Hypersensitivity Immediate Hypersensitivity
Viral Hepatitis	Animal Viral Hepatitis Hepatitis, Viral, Animal Human Viral Hepatitis Viral Hepatitis With Hepatic Coma
Alcoholic Hepatitis	Acute Alcoholic Hepatitis Acute Alcoholic Liver Disease Hepatitis, Alcoholic Hepatitis Alcoholic Ah - [Alcoholic Hepatitis] Ethanol Hepatitis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Cutaneous Leishmaniasis	Diffuse Cutaneous Leishmaniasis Asian Desert Cutaneous Leishmaniasis Leishmaniasis, Cutaneous Leproid Leishmaniasis Leishmaniasis Diffuse Cutaneous Leishmaniasis Cutaneous Ethiopian Cutaneous Leishmaniasis Old World Cutaneous Leishmaniasis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Diabetes Mellitus	Diabetes
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N9965	2'-Fucosyllactose	Inhibitor	99.97%	Phase 2
HY-101132	VB-201		/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99008	Atibuclimab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W251428	Phosphatidylglycerols (egg) sodium salt		99.53%	Unkown
HY-135750	VAF347	Agonist	99.75%	Unkown
HY-W040255	1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine		99.9%	Unkown
HY-182019	HDAC11-IN-5		98.25%	Unkown
HY-161901	BC-1293	Inhibitor	98.40%	Unkown
HY-178049A	UM-259 hydrochloride	Inhibitor	/	Unkown
HY-101132A	(Rac)-VB-201	Inhibitor	/	Unkown
HY-129684	IAXO-101 iodide	Inhibitor	/	Unkown
HY-151399	Antimicrobial agent-5	Inhibitor	/	Unkown
HY-169067	10-Methoxy-canthin-6-one		98.71%	Unkown
HY-D3334	PE-CF594		/	Unkown
HY-RS02189	CD14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09127	NDUFA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16726	Cd14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23162	Cd14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991004	Itanistomig		95.84%	Unkown
HY-P992435	OX118	Inhibitor	/	Unkown
HY-P991845	Anti-CD14 Antibody (UCHM-1)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD14	VGNC	VGNC:70751
Rattus norvegicus	CD14	RGD	RGD:620588
Bos taurus	CD14	VGNC	VGNC:27003
Mus musculus	CD14	MGD	MGI:88318
Felis catus	CD14	VGNC	VGNC:60584
Others	CD14	NCBI