CCR5 Antibody (YA4071)

製品番号: HY-P84374: データシート SDS COA User Guide for Antibodies
FAQs
Technical Support

CCR5 Antibody (YA4071) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR5.

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容量	価格（税別）	在庫状況	数量
10 μL	$96	在庫あり	Estimated Time of Arrival: December 31
50 μL	$252	在庫あり	Estimated Time of Arrival: December 31
100 μL	$408	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

CCR5 Antibody (YA4071) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR5.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 41 kDa;

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

P51681

Gene ID

1234 [NCBI]

Immunogen

Purified recombinant fragment of human CD195 (AA: extra mix) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

純度	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770); (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:It is highly expressed in the spleen, thymus, myeloid cell line THP-1, promyelocytic cell line KG-1a, and CD4+ and CD8+ T cells. Its expression level is moderate in peripheral blood leukocytes and the small intestine. Its expression level is low in the ovary and lung.

Induction: (Microbial infection) May be down-regulated by human cytomegalovirus/HHV-5 protein UL78

Subunit：Interacts with PRAF2 (PubMed:15757671). Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4 (PubMed:10383387, PubMed:11733580, PubMed:8663314, PubMed:8699119). Interacts with GRK2 (PubMed:10085131). Interacts with ARRB1 and ARRB2 (PubMed:11448957, PubMed:16144840). Interacts with CNIH4 (PubMed:24405750). Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis (PubMed:30713770)

RRID

AB_3718894

Synonyms

CCR5; CKR5; CCR-5; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5

ドキュメンテーション

Select Batch:

データシート (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

CCR5 Antibody (YA4071) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CCR5 Antibody (YA4071)

Product Detail

Background

説明

CCR5 Antibody (YA4071) 関連分類

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