CD328 Antibody (YA4583)
(Synonyms: p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1)CD328 Antibody (YA4583) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD328.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD328 Antibody (YA4583) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD328.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Purified recombinant fragment of human CD328 (AA: extra(19-142)) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD328 mediates sialic acid-dependent cell binding, preferentially binding to α-2,3- and α-2,6-linked sialic acids. CD328 also binds to disialiac gangliosides (disialiac galactosylglobulin, disialiac lactotetrasaccharide ceramide, and disialiac GalNAc lactotetrasaccharide ceramide). The sialic acid recognition site may be masked by cis-interactions with sialic acids on the same cell surface. In immune responses, after ligand-induced tyrosine phosphorylation, this molecule may act as an inhibitory receptor, recruiting cytoplasmic phosphatases through its SH2 domain, thereby blocking the dephosphorylation of signaling molecules and inhibiting signal transduction. It mediates the inhibition of natural killer cytotoxicity. CD328 can also inhibit the differentiation of CD34+ cell precursors into myeloid mononuclear cell lineages and the proliferation of myeloid leukemia cells.
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes -
Isoforms & Post-Translational Modification
CD328 has 4 isomers: Q9Y286-1: 51143 Da (predicted); Q9Y286-2: 41237 Da (predicted); Q9Y286-3: 16812 Da (predicted); Q9Y286-4: 16740 Da (predicted).
Tyrosine phosphorylated -
Subunit
Interacts with PTPN6/SHP-1 upon phosphorylation
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SwissProt ID
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Synonyms
p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
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