SIGLEC7 - sialic acid binding Ig like lectin 7 Gene

Also Known as p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27036

About SIGLEC7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,142,301-51,153,526 (from NCBI)

This gene has 6 transcripts (splice variants), 79 orthologues and 16 paralogues. Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues.

Summary

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGLEC7 Products (3)

mRNA	Protein	Name
NM_001277201.2	NP_001264130.1	sialic acid-binding Ig-like lectin 7 isoform 3 precursor
NM_014385.4	NP_055200.1	sialic acid-binding Ig-like lectin 7 isoform 1 precursor
NM_016543.4	NP_057627.2	sialic acid-binding Ig-like lectin 7 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC7 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
400
467 a.a.

Protein Preferred Names	Protein Names
sialic acid-binding Ig-like lectin 7	QA79 membrane protein

Recombinant SIGLEC7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71311	Siglec-7 Protein, Human (HEK293, His)	Q9Y286 (Q19-L353)	≥ 95%, as determined by reducing SDS-PAGE.

SIGLEC7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84886	CD328 Antibody (YA4583)	IHC-P, FC, ELISA	Human
HY-P84886A	CD328 Antibody (YA4583)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iic	CDG2C Congenital Disorder Of Glycosylation Type Iic Leukocyte Adhesion Deficiency Type Ii Cdg Iic Cdgiic Rambam-Hasharon Syndrome Leukocyte Adhesion Deficiency, Type Ii Lad2 Leukocyte Adhesion Deficiency 2 Cdg-Iic Congenital Disorder Of Glycosylation, Type 2c Rhs Cdg Syndrome Type Iic Lad-Ii Rambam Hasharon Syndrome Congenital Disorder Of Glycosylation 2c Glycosylation, Congenital Disorder Of, Type Iic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179153	Siglec-7-IN-1		/	Unkown
HY-E70302	ST8 alpha-2,8-Sialyltransferase 6		/	Unkown
HY-RS12905	SIGLEC7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIGLEC7	MGD	MGI:1932475