Cenexin1 Antibody (YA1805)
(Synonyms: Cenexin 1; Cenexin; CT134; KKT4; ODF 2; ODF 84; odf2; ODF2/1; ODF2/2; ODF84)Cenexin1 Antibody (YA1805) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cenexin1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:100 |
Product Details
Cenexin1 Antibody (YA1805) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cenexin1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 95 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 95 kDa
A synthesized peptide derived from human Cenexin1 / ODF2 aa800-829.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cenexin1 is a Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, cilium; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, spindle pole; Cell projection, cilium, flagellum
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Expression
Tissue_specificity:Testis-specific (at protein level) . Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails -
Isoforms & Post-Translational Modification
Q5BJF6 has 10 isomers: Q5BJF6-1: 95401 Da (predicted); Q5BJF6-2: 88578 Da (predicted); Q5BJF6-3: 93254 Da (predicted); Q5BJF6-4: 95348 Da (predicted); Q5BJF6-5: 73339 Da (predicted); Q5BJF6-6: 75433 Da (predicted); Q5BJF6-7: 80886 Da (predicted); Q5BJF6-8: 73666 Da (predicted); Q5BJF6-9: 66967 Da (predicted); Q5BJF6-10: 75691 Da (predicted).
Tyrosine phosphorylated. Phosphorylated by TSSK4 on Ser-95 -
Subunit
Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network. Interacts via its C-terminus with PLK1 (PubMed:16966375).
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SwissProt ID
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Synonyms
Cenexin 1; Cenexin; CT134; KKT4; ODF 2; ODF 84; odf2; ODF2/1; ODF2/2; ODF84
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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