country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ODF2 - outer dense fiber of sperm tails 2 Gene

Also Known as CT134; ODF84; ODF2/1; ODF2/2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4957

About ODF2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,455,185-128,501,292 (from NCBI)

This gene has 22 transcripts (splice variants), 248 orthologues and 1 paralogue. Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues.

Summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

ODF2 Products (23)

mRNA	Protein	Name
NM_001242352.2	NP_001229281.1	outer dense fiber protein 2 isoform 11
NM_001242353.2	NP_001229282.1	outer dense fiber protein 2 isoform 2
NM_001242354.2	NP_001229283.1	outer dense fiber protein 2 isoform 8
NM_001351577.1	NP_001338506.1	outer dense fiber protein 2 isoform 12
NM_001351578.2	NP_001338507.1	outer dense fiber protein 2 isoform 13
NM_001351579.2	NP_001338508.1	outer dense fiber protein 2 isoform 14
NM_001351580.2	NP_001338509.1	outer dense fiber protein 2 isoform 14
NM_001351581.1	NP_001338510.1	outer dense fiber protein 2 isoform 15
NM_001351582.2	NP_001338511.1	outer dense fiber protein 2 isoform 16
NM_001351583.2	NP_001338512.1	outer dense fiber protein 2 isoform 17
NM_001351584.2	NP_001338513.1	outer dense fiber protein 2 isoform 11
NM_001351585.2	NP_001338514.1	outer dense fiber protein 2 isoform 11
NM_001351586.2	NP_001338515.1	outer dense fiber protein 2 isoform 9
NM_001351587.2	NP_001338516.1	outer dense fiber protein 2 isoform 18
NM_001351588.2	NP_001338517.1	outer dense fiber protein 2 isoform 19
NM_002540.5	NP_002531.3	outer dense fiber protein 2 isoform 9
NM_153432.1	NP_702910.1	outer dense fiber protein 2 isoform 3
NM_153433.2	NP_702911.1	outer dense fiber protein 2 isoform 2
NM_153435.1	NP_702913.1	outer dense fiber protein 2 isoform 1
NM_153436.2	NP_702914.1	outer dense fiber protein 2 isoform 4
NM_153437.3	NP_702915.1	outer dense fiber protein 2 isoform 6
NM_153439.1	NP_702917.1	outer dense fiber protein 2 isoform 5
NM_153440.2	NP_702918.1	outer dense fiber protein 2 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16980960	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17646400	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centriole-centriole cohesion	IGI IGI: Inferred from genetic interaction	23213374	GOA
involved in cilium organization	IGI IGI: Inferred from genetic interaction	23400999	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	23213374	GOA
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of centriolar subdistal appendage	IDA IDA: Inferred from direct assay	23213374	GOA
located in centriole	IDA IDA: Inferred from direct assay	17646400	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	17646400	GOA
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
outer dense fiber protein 2	cancer/testis antigen 134

ODF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ODF2	Q5BJF6	NUFIP2	Homo sapiens	Q7Z417	Anti Bait CoIP	35709258

Cross: Cross-species interaction Intra: Intraspecies interaction

ODF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82060	Cenexin1 Antibody (YA1805)	WB, FC	Human

Related Diseases

Diseases	Alias
Spermatogenic Failure 8	SPGF8
Latex Allergy
Infertility
Seckel Syndrome 7	SCKL7 Microcephalic Primordial Dwarfism, Dauber Type Seckel Syndrome, Type 7
Orofaciodigital Syndrome Ix	OFD9 Orofaciodigital Syndrome With Retinal Abnormalities Oral-Facial-Digital Syndrome With Retinal Abnormalities Orofaciodigital Syndrome 9 Oral-Facial-Digital Syndrome Type 9 Ofds Ix Oral-Facial-Digital Syndrome, Type Ix Ofd Syndrome 9 Ofds 9 Oral Facial Digital Syndrome 9 Oral Facial Digital Syndrome Type 9 Orofaciodigital Syndrome Type 9 Orofaciodigital Syndrome, Type Ix
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)
Pelvic Varices	Varix Of Pelvis Pelvic Varicose Vein
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09751	ODF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09752	ODF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ODF2	VGNC	VGNC:68619
Bos taurus	ODF2	VGNC	VGNC:32401
Macaca mulatta	ODF2	VGNC	VGNC:75580
Mus musculus	ODF2	MGD	MGI:1098824
Canis familiaris	ODF2	VGNC	VGNC:44099
Rattus norvegicus	ODF2	RGD	RGD:3229