IL-15 Antibody (YA7227)
(Synonyms: Interleukin-15, IL-15, IL15)
Based on 1 Customer Validation
IL-15 Antibody (YA7227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-15.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:50-100 | 1:50-200 |
Product Details
IL-15 Antibody (YA7227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-15.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 13 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 18 kDa
A synthesized peptide derived from human IL 15: 100-162.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Interleukin-5 (IL-5) is a key cytokine that orchestrates the differentiation, survival, and activation of eosinophils[1][2]. Mechanistically, IL-5 signals through the IL-5 receptor (IL-5R), a heterodimer composed of a unique α subunit and a shared βc subunit, triggering JAK/STAT, PI3K, and MAPK pathways to modulate immune responses[3][4]. In disease models, IL-5 drives eosinophilic inflammation in asthma, hypereosinophilic syndrome, and other allergic conditions, serving as a validated biomarker and therapeutic target[5][6]. Compared with related cytokine isoforms such as IL-3 and GM-CSF, IL-5 exhibits selective potency toward eosinophils, with minimal effects on neutrophils or basophils[3][7]. Pharmacologic inhibition of IL-5 using monoclonal antibodies or receptor antagonists effectively reduces eosinophil counts and mitigates tissue inflammation in preclinical and clinical studies[5][6]. For experimental applications, IL-5 agonists are utilized to expand eosinophil populations in vitro and in vivo, facilitating mechanistic studies of allergic inflammation and immune regulation[2][8]. Collectively, IL-5 serves as a central mediator in eosinophil biology, linking receptor-specific signaling to disease pathogenesis and therapeutic intervention strategies[1][5][6].
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Subcellular Localization
Secreted,Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus
Induction: By interferon-gamma -
Isoforms & Post-Translational Modification
P40933 has two isomers: P40933-1: 18086 Da (predicted); P40933-2: 14912 Da (predicted).
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SwissProt ID
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Synonyms
Interleukin-15, IL-15, IL15
Documentation
References
[1]. Philbin VJ, et al. Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol. 2012;130(1):195-204.e9. [Content Brief]
[2]. Elias M, et al. IL-36 in chronic inflammation and fibrosis - bridging the gap? J Clin Invest. 2021;131(2):e144336. [Content Brief]
[3]. Queen D, et al. Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development. Front Cell Dev Biol. 2019;7:317. [Content Brief]
[5]. Boutet MA, et al. IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential. Int J Mol Sci. 2019;20(6):1257. [Content Brief]
[8]. Speer EM, et al. Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. PLoS One. 2018;13:e0196352. [Content Brief]
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