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KLRG1 Antibody (YA1422)

(Synonyms: 2F1 Ag; CLEC15A; KLRG1; MAFA 2F1; MAFA L; MAFA like; MAFAL)
Customer Review

Based on 1 Customer Validation

KLRG1 Antibody (YA1422) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLRG1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    1.Supplied in PBS, pH 7.4, 5% - 8% trehalose.
    2.Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
    Please refer to the lot-specific COA for specific buffer information.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for KLRG1 Antibody (YA1422)
  • KLRG1 Antibody (YA1422) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:50-1:100 1:10000

Product Details

Description

KLRG1 Antibody (YA1422) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KLRG1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 38 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 22 kDa
Species Reactivity Database

Entrez Gene: 10219 Human

SwissProt: Q96E93 Human

Immunogen

Recombinant human KLRG1 protein

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    1.Supplied in PBS, pH 7.4, 5% - 8% trehalose.
    2.Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
    Please refer to the lot-specific COA for specific buffer information.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for KLRG1 Antibody (YA1422)
    Flow cytometric analysis of 1X106 A549 cells labeling KLRG1 Antibody(HY-P81677, red). Cells stained with the primary antibody at 1/50 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Rabbit IgG H&L (HY-P8002) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Rabbit IgG Isotype Control (HY-P80879, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

Background

  • Function

    KLRG1 plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells

  • Subcellular Localization

    Cell membrane; Single-pass type II membrane protein

  • Expression


    Tissue_specificity:Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells

    Induction:By pathogens and viruses infections

  • Isoforms & Post-Translational Modification

    Q96E93 has 2 isomers: Q96E93-1: 21831 Da (predicted); Q96E93-2: 21206 Da (predicted).

  • Subunit

    Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D

  • SwissProt ID

    Q96E93

  • Gene ID
    10219 [NCBI]
  • Synonyms

    2F1 Ag; CLEC15A; KLRG1; MAFA 2F1; MAFA L; MAFA like; MAFAL

  • Research Field

    Immunology

KLRG1 Antibody (YA1422) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Flow cytometric analysis of 1X106 A549 cells labeling KLRG1 Antibody(HY-P81677, red). Cells stained with the primary antibody at 1/50 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Rabbit IgG H&L (HY-P8002) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Rabbit IgG Isotype Control (HY-P80879, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • KLRG1 Antibody (YA1422) Product Image
    1/16
  • Experimental Validation Results for KLRG1 Antibody (YA1422)
  • KLRG1 Antibody (YA1422) Product Image
  • Experimental Validation Results for KLRG1 Antibody (YA1422)
    1/1
    MedChemExpress Validation
     Flow cytometric analysis of 1X106 A549 cells labeling KLRG1 Antibody(HY-P81677, red). Cells stained with the primary antibody at 1/50 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Rabbit IgG H&L (HY-P8002) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Rabbit IgG Isotype Control (HY-P80879, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Experimental Validation Results for KLRG1 Antibody (YA1422)
  • KLRG1 Antibody (YA1422) Product Image
    MedChemExpress Validation

    Flow cytometric analysis of 1X106 A549 cells labeling KLRG1 Antibody(HY-P81677, red). Cells stained with the primary antibody at 1/50 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Rabbit IgG H&L (HY-P8002) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Rabbit IgG Isotype Control (HY-P80879, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • KLRG1 Antibody (YA1422) Product Image FC