KLRG1 - killer cell lectin like receptor G1 Gene

Also Known as 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10219

About KLRG1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,950,044-9,215,570 (from NCBI)

This gene has 7 transcripts (splice variants), 107 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

KLRG1 Products (5)

mRNA Protein Name
NM_001329099.2 NP_001316028.1 killer cell lectin-like receptor subfamily G member 1 isoform a
NM_001329101.2 NP_001316030.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329102.2 NP_001316031.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329103.2 NP_001316032.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_005810.4 NP_005801.3 killer cell lectin-like receptor subfamily G member 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRG1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (93 - 186)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

killer cell lectin-like receptor subfamily G member 1

  • C-type lectin domain family 15 member A

KLRG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLRG1 Q96E93 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
KLRG1 Q96E93 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
KLRG1 Q96E93 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
KLRG1 Q96E93 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
KLRG1 Q96E93 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
KLRG1 Q96E93 LEPROTL1 Homo sapiens O95214
Y2H Pooling
16189514
Intra
KLRG1 Q96E93 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71607 KLRG1 Protein, Human (His-SUMO) Q96E93 (L60-F195) ≥ 95%, as determined by reducing SDS-PAGE.

KLRG1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81677 KLRG1 Antibody (YA1422) FC, ELISA Human

Related Diseases

Diseases Alias
Mastocytosis

  • Mast Cell Disease

  • Mast Cell Hyperplasia

  • Urticaria Pigmentosa

  • Malignant Mastocytoma

  • Malignant Mast Cell Tumours

  • Malignant Mastocytosis
Thyroid Dyshormonogenesis 3

  • TDH3

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

  • Thyroid Hormonogenesis, Genetic Defect In, 3

  • Genetic Defect In Thyroid Hormonogenesis 3

  • Chdh3

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

  • Genetic Defect In Thyroid Hormonogenesis Type 3
Mast-Cell Leukemia

  • Mast Cell Leukemia

  • Leukemia, Mast-Cell

  • Leukemia Mast Cell

  • Mast Cell Leukaemia Nos

  • Mast Cell Leukaemia Without Mention Of Remission
Macular Degeneration, Age-Related, 8

  • Age Related Macular Degeneration 8

  • ARMD8

  • Macular Degeneration, Age-Related, Type 8
Systemic Mastocytosis

  • Systemic Mast Cell Disease

  • Systemic Tissue Mast Cell Disease

  • Mastocytosis, Systemic

  • Smcd - Systemic Mast Cell Disease

  • Smcd

  • Mast Cell Disease, Systemic

  • Systemic Mast-Cell Disease

  • Systemic Mastocytoses

  • Mastocytosis Systemic

  • Corneal Dystrophy, Subepithelial Mucinous

  • Smcd - [Systemic Mast Cell Disease]
Listeriosis

  • Listeria Infection

  • Infection By Listeria Monocytogenes

  • Listeria Monocytogenes Infection

  • Listeria Infections

  • Listerial Foodborne Infection

  • Circling Disease

  • Infection Due To Listeria Monocytogenes

  • Listerellosis
Dermatitis, Atopic, 5

  • ATOD5

  • Atopic Dermatitis 5

  • Dermatitis, Atopic, Susceptibility To, 5

  • Dermatitis, Atopic 5
Bronchiectasis 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990026 Ulviprubart Modulator 99.39% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07397 KLRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17468 Klrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23926 Klrg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990205 Anti-Mouse/Human KLRG-1 Antibody (2F1) Inhibitor 95.00% Unkown
HY-P990026A Ulviprubart (FUT8-KO) Inhibitor / Unkown
HY-P991295 ABC-015 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLRG1 VGNC VGNC:74196
Rattus norvegicus KLRG1 RGD RGD:61978
Bos taurus KLRG1 VGNC VGNC:30687
Canis familiaris KLRG1 VGNC VGNC:42487
Mus musculus KLRG1 MGD MGI:1355294
Macaca fascicularis KLRG1 NCBI NCBI:102130067
Others KLRG1 NCBI