KLRG1 - killer cell lectin like receptor G1 Gene

Homo sapiens

Also known as 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE

Gene ID: 10219 | Gene type: protein coding

About KLRG1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,950,044-9,215,570 (from NCBI)

This gene has 7 transcripts (splice variants), 107 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

KLRG1 Products(5)

mRNA	Protein	Name
NM_001329099.2	NP_001316028.1	killer cell lectin-like receptor subfamily G member 1 isoform a
NM_001329101.2	NP_001316030.1	killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329102.2	NP_001316031.1	killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329103.2	NP_001316032.1	killer cell lectin-like receptor subfamily G member 1 isoform c
NM_005810.4	NP_005801.3	killer cell lectin-like receptor subfamily G member 1 isoform b

KLRG1 Protein Structure

Lectin_C

0
100
195 a.a.

Protein Preferred Names

Protein Names

killer cell lectin-like receptor subfamily G member 1

C-type lectin domain family 15 member A

Recombinant KLRG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71607	KLRG1 Protein, Human (His-SUMO)	Q96E93 (L60-F195)	≥95%

Related Diseases

Diseases

Alias

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Thyroid Dyshormonogenesis 3

TDH3	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3
Thyroid Hormonogenesis, Genetic Defect In, 3	Genetic Defect In Thyroid Hormonogenesis 3
Chdh3	Congenital Hypothyroidism Due To Dyshormonogenesis Type 3
Genetic Defect In Thyroid Hormonogenesis Type 3

Mast-Cell Leukemia

Mast Cell Leukemia	Leukemia, Mast-Cell
Leukemia Mast Cell	Mast Cell Leukaemia Nos
Mast Cell Leukaemia Without Mention Of Remission

Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8	ARMD8
Macular Degeneration, Age-Related, Type 8

Systemic Mastocytosis

Systemic Mast Cell Disease	Systemic Tissue Mast Cell Disease
Mastocytosis, Systemic	Smcd - Systemic Mast Cell Disease
Smcd	Mast Cell Disease, Systemic
Systemic Mast-Cell Disease	Systemic Mastocytoses
Mastocytosis Systemic	Corneal Dystrophy, Subepithelial Mucinous
Smcd - [Systemic Mast Cell Disease]

Listeriosis

Listeria Infection	Infection By Listeria Monocytogenes
Listeria Monocytogenes Infection	Listeria Infections
Listerial Foodborne Infection	Circling Disease
Infection Due To Listeria Monocytogenes	Listerellosis

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Bronchiectasis 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07397	KLRG1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLRG1	VGNC	VGNC:74196
Rattus norvegicus	KLRG1	RGD	RGD:61978
Bos taurus	KLRG1	VGNC	VGNC:30687
Canis familiaris	KLRG1	VGNC	VGNC:42487
Mus musculus	KLRG1	MGD	MGI:1355294
Others	KLRG1	NCBI

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