LOX1 Antibody (YA1300)
(Synonyms: OLR1, CLEC8A)LOX1 Antibody (YA1300) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LOX1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, Glycerol and BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50 | 1:50-1:100 |
Product Details
LOX1 Antibody (YA1300) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LOX1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size:55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 31 kDa
Peptide
Endogenous
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS, Glycerol and BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Unlike native low-density lipoprotein (LDL), modified LDL such as oxidized, carbamylated, or acetylated LDL are not recognized by the native LDL receptor (LDL-R) .1 Rather, modified LDL binds to the lectin-like oxidized LDL receptor-1 (LOX-1) .Upon activation by modified LDL, LOX-1 induces endothelial dysfunction and uptake of the modified lipids.2 Endothelial dysfunction is the first stage in atherogenesis.3 Thus, the identification of LOX-1 through expression cloning as a major receptor for oxLDL in endothelial cells (ECs) supports a putative role for modified LDL in atherogenesis and has taken centre stage in cardiovascular research.
-
Subcellular Localization
Cell membrane; Lipid-anchor; Cell membrane; Single-pass type II membrane protein; Membrane raft; Secreted
-
Expression
Tissue_specificity:Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level
Induction:By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction -
Isoforms & Post-Translational Modification
P78380 has 3 isomers: P78380-1: 30959 Da (predicted); P78380-2: 20227 Da (predicted); P78380-3: 21425 Da (predicted).
The intrachain disulfide-bonds prevent N-glycosylation at some sites;N-glycosylated -
Subunit
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70
-
SwissProt ID
-
Synonyms
OLR1, CLEC8A
-
Research Field
Cell biology
Documentation
Powered by Bioz
