OLR1 - oxidized low density lipoprotein receptor 1 Gene

Also Known as LOX1; LOXIN; SLOX1; CLEC8A; SCARE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4973

About OLR1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,158,301-10,176,266 (from NCBI)

This gene has 11 transcripts (splice variants), 368 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 50.3), lung (RPKM 32.5) and 5 other tissues.

Summary

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced Apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

OLR1 Products (3)

mRNA	Protein	Name
NM_001172632.2	NP_001166103.1	oxidized low-density lipoprotein receptor 1 isoform 2
NM_001172633.2	NP_001166104.1	oxidized low-density lipoprotein receptor 1 isoform 3
NM_002543.4	NP_002534.1	oxidized low-density lipoprotein receptor 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15939022	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24846140	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLR1 Protein Structure

Lectin_C

0
100
200
273 a.a.

Protein Preferred Names	Protein Names
oxidized low-density lipoprotein receptor 1	C-type lectin domain family 8 member A

OLR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OLR1	P78380	TCP1	Homo sapiens	P17987	Pull Down	24846140
Intra	OLR1	P78380	TCP1	Homo sapiens	P17987	Anti Bait CoIP	24846140
Intra	OLR1	P78380	CCT4	Homo sapiens	P50991	Anti Bait CoIP	24846140
Intra	OLR1	P78380	CCT4	Homo sapiens	P50991	Pull Down	24846140
Intra	OLR1	P78380	HSPA1L	Homo sapiens	P34931	Fluorescence	15792802
Intra	OLR1	P78380	q9bu08_human	Homo sapiens	Q9BU08	Pull Down	24846140
Intra	OLR1	P78380	OLR1	Homo sapiens	P78380	X-Ray Diffraction	15939022
Intra	OLR1	P78380	CCT3	Homo sapiens	P49368	Pull Down	24846140
Intra	OLR1	P78380	OLR1	Homo sapiens	P78380	Solution Sedimentation	15939022
Intra	OLR1	P78380	CCT6A	Homo sapiens	P40227	Pull Down	24846140
Intra	OLR1	P78380	CCT7	Homo sapiens	Q99832	Pull Down	24846140
Intra	OLR1	P78380	OLR1	Homo sapiens	P78380	Comigration in SDS	15939022
Intra	OLR1	P78380	OLR1	Homo sapiens	P78380	GMS	19664054
Intra	OLR1	P78380	F5	Homo sapiens	P12259	Anti Tag CoIP	28514442
Intra	OLR1	P78380	F5	Homo sapiens	P12259	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OLR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71180	LOX-1/OLR1 Protein, Human (HEK293, His)	P78380-1 (S61-Q273)	≥ 95%, as determined by reducing SDS-PAGE.

OLR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81172	LOX 1 Antibody	WB, IHC-P, ICC/IF, FC	Human, Rat, Rabbit
HY-P81555	LOX1 Antibody (YA1300)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Exfoliation Syndrome	Pseudoexfoliation Glaucoma Pseudoexfoliation Syndrome Exfoliation Syndrome, Susceptibility To XFS Exfoliation Glaucoma Xfg Pseudoexfoliation Of The Lens Pexg Pexs Exfoliative Syndrome Glaucoma Capsulare Pex Pseudo-Exfoliation Syndrome
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Diabetes Mellitus	Diabetes
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Aortic Atherosclerosis	Atherosclerosis Of Aorta Aorta Atheroma Aorta Calcification Aorta Arteriosclerosis Aortic Degeneration Aortic Calcification Aortic Atheroma Aortic Arteriosclerotic Disease Aortic Arteriosclerosis Aorta Sclerosis Aorta Degeneration Atheromatous Aortic Calcified Aortic Stenosis Atheromatous Aorta Arteriosclerotic Aortitis Arteriosclerotic Aortic Stenosis Arteriosclerotic Aorta Disease Aortic Sclerosis
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16991	Olr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09780	OLR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23434	Olr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OLR1	VGNC	VGNC:75583
Mus musculus	OLR1	MGD	MGI:1261434
Bos taurus	OLR1	VGNC	VGNC:32427
Rattus norvegicus	OLR1	RGD	RGD:620515
Canis familiaris	OLR1	VGNC	VGNC:44120
Felis catus	OLR1	VGNC	VGNC:68624
Others	OLR1	NCBI