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Cat. No.: HY-P84288A

LTBR Antibody (YA3985)(PBS only)

Name: LTBR Antibody (YA3985)(PBS only)
Brand: MedChemExpress
SKU: HY-P84288A
Availability: PreOrder

(Synonyms: TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III)

LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:400	1:10000

Description

LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

Host Mouse
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 47 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 47 kDa

Immunogen

Purified recombinant fragment of human LTBR (AA: extra 31-227) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2a

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

LTBR receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA(1)-LTB(2)). Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs^[1].
Subcellular Localization

Membrane; Single-pass type I membrane protein
Isoforms & Post-Translational Modification

P36941 has 2 isomers: P36941-1: 46709 Da (predicted); P36941-2: 44810 Da (predicted).
Subunit

Self-associates; dimerization and trimerization are promoted by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355). Associates with TRAF3 (PubMed:8663299). Associates with TRAF4 (PubMed:9626059). Associates with TRAF5 (PubMed:9511754). Interacts with Aedes aegypti lymphotoxin beta receptor inhibitor; the interaction reduces dimerization and trimerization of LTBR induced by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355, PubMed:38248473)
SwissProt ID

P36941
Gene ID

4055 [NCBI]
Synonyms

TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III