LTBR Antibody (YA3985)(PBS only)

Cat. No.: HY-P84288A: Data Sheet User Guide for Antibodies
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LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LTBR Antibody (YA3985) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LTBR.

Host

Mouse

Molecular Weight

Predicted band size: 47 kDa;

Observed band size: 47 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P36941

Gene ID

4055 [NCBI]

Immunogen

Purified recombinant fragment of human LTBR (AA: extra 31-227) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT (PubMed:24248355). Activates NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA(1)-LTB(2)) (PubMed:24248355). Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs

Subcellular Localization：Membrane; Single-pass type I membrane protein

Isoforms & Post-Translational Modification：P36941 has 2 isomers: P36941-1: 46709 Da (predicted); P36941-2: 44810 Da (predicted).

Subunit：Self-associates; dimerization and trimerization are promoted by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355). Associates with TRAF3 (PubMed:8663299). Associates with TRAF4 (PubMed:9626059). Associates with TRAF5 (PubMed:9511754). Interacts with Aedes aegypti lymphotoxin beta receptor inhibitor; the interaction reduces dimerization and trimerization of LTBR induced by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355, PubMed:38248473)

Synonyms

TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III

Documentation

User Guide for Antibodies (1077 KB)